journal article·2012-12-18

Multicompartment Intracellular Self‐Expanding Nanogel for Targeted Delivery of Drug Cocktail

Remant Bahadur K. C., Peisheng Xu

Advanced Materials· Volume 24· Issue 48
Publisher page

Abstract

A nano cocktail, NCPD, fabricated from a pH and redox dual responsive polymer shows a multicompartment structure. The NCPD nanogel is stable in physiological environments while intracellular spontaneous swelling and fast releasing its payload. NCPD displays much stronger synergism than its free drug counterpart, which suggests that NCPD could greatly attenuate the side effects of drug cocktails while boosting synergistic anticancer effects. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (20)

Show source-provided references
1. 10.1056/NEJM19950817333071010.1056/NEJM199508173330710 ↗
2. Butters D. J. · Cochrane Database Syst. Rev. · 2010 · 11 · CD003368
3. 10.1038/nbt.154910.1038/nbt.1549 ↗
4. 10.1016/S0168-3659(99)00248-510.1016/S0168-3659(99)00248-5 ↗
5. Fang J. · Adv. Drug Delivery Rev. · 2010
6. 10.1007/0-306-47932-X_210.1007/0-306-47932-X_2 ↗
7. 10.1038/nrd261410.1038/nrd2614 ↗
8. 10.1586/17434440.4.2.13110.1586/17434440.4.2.131 ↗
9. 10.3181/0808-MR-25010.3181/0808-MR-250 ↗
10. 10.1021/bm050902y10.1021/bm050902y ↗
11. 10.1007/s00280-006-0287-510.1007/s00280-006-0287-5 ↗
12. 10.1021/bm050357110.1021/bm0503571 ↗
13. 10.1016/j.ijpharm.2009.04.02110.1016/j.ijpharm.2009.04.021 ↗
14. 10.1016/j.biomaterials.2011.03.06010.1016/j.biomaterials.2011.03.060 ↗
15. 10.1016/j.jconrel.2011.01.03010.1016/j.jconrel.2011.01.030 ↗
16. 10.1021/mp800137z10.1021/mp800137z ↗
17. 10.1002/anie.20060525410.1002/anie.200605254 ↗
18. 10.1091/mbc.01-06-030810.1091/mbc.01-06-0308 ↗
19. 10.1016/j.ijpharm.2009.08.04110.1016/j.ijpharm.2009.08.041 ↗
20. 10.1158/0008-5472.CAN-09-194710.1158/0008-5472.CAN-09-1947 ↗