Strategy to Efficient Photodynamic Therapy for Antibacterium: Donor‐Acceptor Structure in Hydrogen‐Bonded Organic Framework

Abstract While the construction of a donor‐acceptor (D‐A) structure has gained great attention across various scientific disciplines, such structures are seldomly reported within the field of hydrogen‐bonded organic frameworks (HOFs). Herein, a D‐A based HOF is synthesized, where the adjacent D‐A pairs are connected by hydrogen bonds instead of the conventionally employed covalent bonds. This structural feature imparts material with a reduced energy gap between excited state and triplet state, thereby facilitating the intersystem crossing (ISC) and boosting the generation rate of single oxygen (quantum yield = 0.98). Consequently, the resulting material shows high performance for antimicrobial photodynamic therapy (PDT). The impact of D‐A moiety is evident when comparing this finding to a parallel study conducted on an isoreticular HOF without a D‐A structure. The study presented here provides in‐depth insights into the photophysical properties of D‐A pair in a hydrogen‐bonded network, opening a new avenue to the design of innovative materials for efficient PDT.