journal article·2016-10

Biocompatible Red Fluorescent Organic Nanoparticles with Tunable Size and Aggregation‐Induced Emission for Evaluation of Blood–Brain Barrier Damage

Xiaolei Cai, Aishwarya Bandla, Duo Mao, Guangxue Feng, Wei Qin, Lun‐De Liao, Nitish Thakor, Ben Zhong Tang, Bin Liu

Advanced Materials· Volume 28· Issue 39
Publisher page

Abstract

Detection of damage to the blood-brain barrier (BBB) is important for the diagnosis of brain diseases and therapeutic drug evaluation. The widely used probe, Evans blue, suffers from low specificity and high toxicity in vivo. It is shown that organic nanoparticles with tuneable size, good biocompatibility, and aggregation-induced emission characteristics offer high detection specificity to detect BBB damage via a photothrombotic ischemia rat model.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Luminescence and Fluorescent Materials · Nanoplatforms for cancer theranostics · Molecular Sensors and Ion Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical and Biomolecular Engineering National University of Singapore 4 Engineering Drive 4 Singapore 117585

NUS Graduate School for Integrative Sciences and Engineering National University of Singapore 28 Medical Drive, #05‐01 Singapore 117456

Singapore Institute for Neurotechnology (SINAPSE) National University of Singapore 28 Medical Drive Singapore 117456

Department of Biomedical Engineering National University of Singapore 21 Lower Kent Ridge Road Singapore 119077

Department of Chemistry and Division of Biomedical Engineering Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong 999077

Institute of Biomedical Engineering and Nanomedicine National Health Research Institutes 35 Keyan Road, Zhunan Town Miaoli County 35053 Taiwan

Institute of Materials Research and Engineering 2 Fusionopolis Way, Innovis, #08‐03 Singapore 138634

Funding

National Research Foundation Singapore · National University of Singapore · Institute of Materials Research and Engineering

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