DataVXAdvanced MaterialsPaper
journal article·2022-08

Composition‐Dependent Enzyme Mimicking Activity and Radiosensitizing Effect of Bimetallic Clusters to Modulate Tumor Hypoxia for Enhanced Cancer Therapy

Yue Hua, Jia‐Hong Huang, Zi‐Hui Shao, Xi‐Ming Luo, Zhao‐Yang Wang, Jun‐Qi Liu, Xueli Zhao, Xiaoyuan Chen, Shuang‐Quan Zang

Advanced Materials· Volume 34· Issue 31
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Source abstract

Abstract

Abstract Alloying is an efficient chemistry to tailor the properties of metal clusters. As a class of promising radiosensitizers, most previously reported metal clusters exhibit unitary function and cannot overcome radioresistance of hypoxic tumors. Here, atomically precise alloy clusters Pt2M4 (M = Au, Ag, Cu) are synthesized with bright luminescence and adequate biocompatibility, and their composition‐dependent enzyme mimicking activity and radiosensitizing effect is explored. Specifically, only the Pt2Au4 cluster displays catalase‐like activity, while the others do not have clusterzyme properties, and its radiosensitizing effect is the highest among all the alloy clusters tested. By taking advantage of the sustainable production of O2 via the decomposition of endogenous H2O2, the Pt2Au4 cluster modulates tumor hypoxia as well as increases the efficacy of radiotherapy. This work thus advances the cluster alloying strategy to produce multifunctional therapeutic agents for improving hypoxic tumor therapy.
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Research context

Metals & alloysBiomaterials

OpenAlex topics: Nanocluster Synthesis and Applications · Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostic Cluster Materials Green Catalysis Center and College of Chemistry Zhengzhou University Zhengzhou 450001 China

The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou 450000 China

Departments of Diagnostic Radiology Chemical and Biomolecular Engineering and Biomedical Engineering National University of Singapore Singapore 117545 Singapore

Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore

Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Funding

National Science Fund for Distinguished Young Scholars · National Natural Science Foundation of China · China Postdoctoral Science Foundation · State Tobacco Monopoly Administration · National University of Singapore · National Medical Research Council

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