journal article·2022-05Open access

Molecular Programming of NIR‐IIb‐Emissive Semiconducting Small Molecules for In Vivo High‐Contrast Bioimaging Beyond 1500 nm

Yi Yuan, Zhe Feng, Shengliang Li, Zhongming Huang, Yingpeng Wan, Chen Cao, Sien Lin, Lan Wu, Jing Zhou, Liang‐Sheng Liao, Jun Qian, Chun‐Sing Lee

Advanced Materials· Volume 34· Issue 19

Abstract

Abstract Materials with long‐wavelength second near‐infrared (NIR‐II) emission are highly desired for in vivo dynamic visualizating of microstructures in deep tissues. Herein, by employing an atom‐programming strategy, a series of highly fluorescent semiconducting oligomers (SOMs) with tunable NIR‐IIb emissions are developed for bioimaging applications. After self‐assembly into nanoparticles (NPs), they show good brightness, high photostability, and satisfactory biocompatibility. The SOM NPs are applied as probes for high‐resolution imaging of whole‐body and hind‐limb blood vessels, biliary tract, and bladder with their emissions over 1500 nm. This work demonstrates an atom‐programming strategy for constructing semiconducting small molecules with enhanced NIR‐II fluorescence for deep‐tissue imaging, affording new insight for advancing molecular design of NIR‐II fluorophores.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Perovskite Materials and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Pharmaceutical Sciences Soochow University Suzhou 215123 P. R. China

Center of Super‐Diamond and Advanced Films (COSDAF) Department of Chemistry City University of Hong Kong 83 Tat Chee Avenue Kowloon Hong Kong 000000 P. R. China

State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic Research College of Optical Science and Engineering International Research Center for Advanced Photonics Zhejiang University Hangzhou 310058 P. R. China

School of Chemistry and Chemical Engineering University of South China Hengyang 421001 P. R. China

Department of Orthopaedics & Traumatology Stem Cells and Regenerative Medicine Laboratory Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Prince of Wales Hospital Shatin Hong Kong 000000 P. R. China

Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon‐Based Functional Materials and Devices Soochow University Suzhou 215123 P. R. China

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities

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