DataVXAdvanced MaterialsPaper
journal article·2020-09

A Non‐Invasive Nanoprobe for In Vivo Photoacoustic Imaging of Vulnerable Atherosclerotic Plaque

Xiaoxiao Ge, Hongtu Cui, Jian Kong, Shi‐Yu Lu, Rui Zhan, Jianing Gao, Yangkai Xu, Shuangyan Lin, Kaixin Meng, Lingyun Zu, Shaojun Guo, Lemin Zheng

Advanced Materials· Volume 32· Issue 38
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Source abstract

Abstract

Abstract Vulnerable atherosclerotic (AS) plaque is the major cause of cardiovascular death. However, clinical methods cannot directly identify the vulnerable AS plaque at molecule level. Herein, osteopontin antibody (OPN Ab) and NIR fluorescence molecules of ICG co‐assembled Ti3C2 nanosheets are reported as an advanced nanoprobe (OPN Ab/Ti3C2/ICG) with enhanced photoacoustic (PA) performance for direct and non‐invasive in vivo visual imaging of vulnerable AS plaque. The designed OPN Ab/Ti3C2/ICG nanoprobes successfully realize obvious NIR fluorescence imaging toward foam cells as well as the vulnerable AS plaque slices. After intravenous injection of OPN Ab/Ti3C2/ICG nanoprobes into AS model mice, in vivo imaging results show a significantly enhanced PA signal in the aortic arch accumulated with vulnerable plaque, well indicating the remarkable feasibility of OPN Ab/Ti3C2/ICG nanoprobes to distinguish the vulnerable AS plaque. The proposed OPN Ab/Ti3C2/ICG nanoprobes not only overcome the clinical difficulty to differentiate vulnerable plaque, but also achieve the non‐invasively specific in vivo imaging of vulnerable AS plaque at molecule level, greatly promoting the innovation of cardiovascular diagnosis technology.
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Research context

Nanomaterials

OpenAlex topics: Photoacoustic and Ultrasonic Imaging · Nanoplatforms for cancer theranostics · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine School of Basic Medical Sciences Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Health Sciences Center Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China

Department of Hepatobilitary Surgery Chaoyang Hospital Capital Medical University Beijing 100043 China

Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of Education School of Physics and Electronic Engineering Harbin Normal University Harbin 150025 China

Department of Cardiovascular Medicine Peking University Third Hospital Beijing 100191 China

BIC‐ESAT College of Engineering Peking University Beijing 100871 China

Department of Energy and Resources Engineering College of Engineering Peking University Beijing 100871 China

China National Clinical Research Center for Neurological Diseases Advanced Innovation Center for Human Brain Protection Beijing Tiantan Hospital The Capital Medical University Beijing 100050 China

Funding

National Natural Science Foundation of China · Beijing Municipal Natural Science Foundation · China Postdoctoral Science Foundation

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