DataVXAdvanced MaterialsPaper
journal article·2020-04

Dendronized‐Polymer Disturbing Cells' Stress Protection by Targeting Metabolism Leads to Tumor Vulnerability

Dayi Pan, Xiuli Zheng, Qianfeng Zhang, Zhiqian Li, Zhenyu Duan, Wen Zheng, Meng Gong, Hongyan Zhu, Hu Zhang, Qiyong Gong, Zhongwei Gu, Kui Luo

Advanced Materials· Volume 32· Issue 14
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Source abstract

Abstract

Abstract Metabolic demand of cancer is quite unique compared to normal tissues and this is an emerging hallmark of cancer, which brings a potential opportunity to discover drugs that target cancer cell metabolism. Herein, the development of a dendronized pyropheophorbide a (Ppa)‐conjugated polymer (DPP) is reported, and a linear Ppa‐conjugated polymer (LPP) is reported as a control. DPP is found to disturb cellular metabolism including increased energy depletion, dysfunctional H+ regulation, and decreased antioxidation, resulting in deficiency in protecting cells from stresses. These vulnerable cells are subjected to photodynamic therapy (PDT) treatment in the presence of DPP, resulting in attenuated cancer cell growth and eventually cell death. The in vivo anticancer efficacy is also ascribed to significantly prolonged blood circulation and enhanced tumor accumulation of DPP due to its unique molecular structure. This study presents a new platform using dendronized polymers for tumor suppression by targeting cancer cell metabolism.
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Research context

Polymers

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer, Hypoxia, and Metabolism · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Huaxi MR Research Center (HMRRC) Department of Radiology Functional and molecular imaging Key Laboratory of Sichuan Province National Clinical Research Center for Geriatrics State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China

West China‐Washington Mitochondria and Metabolism Research Center West China Hospital Sichuan University Chengdu 610041 China

Laboratory of Stem Cell Biology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China

Amgen Bioprocessing Centre Keck Graduate Institute Claremont CA 91711 USA

National Engineering Research Center for Biomaterials Sichuan University Chengdu 610064 China

Funding

National Natural Science Foundation of China · Department of Science and Technology of Sichuan Province · Ministry of Science and Technology of the People's Republic of China · China Postdoctoral Science Foundation · Fundamental Research Funds for the Central Universities · West China Hospital, Sichuan University

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