Cuproptosis Induced by ROS Responsive Nanoparticles with Elesclomol and Copper Combined with αPD‐L1 for Enhanced Cancer Immunotherapy (Adv. Mater. 22/2023)

Boda Guo; Feiya Yang; Lingpu Zhang; Qinxin Zhao; Wenkuan Wang; Lu Yin; Dong Chen; Mingshuai Wang; Sujun Han; Haihua Xiao; Nianzeng Xing

doi:10.1002/adma.202370152

journal article·2023-06Open access

Cuproptosis Induced by ROS Responsive Nanoparticles with Elesclomol and Copper Combined with αPD‐L1 for Enhanced Cancer Immunotherapy (Adv. Mater. 22/2023)

Boda Guo, Feiya Yang, Lingpu Zhang, Qinxin Zhao, Wenkuan Wang, Lu Yin, Dong Chen, Mingshuai Wang, Sujun Han, Haihua Xiao, Nianzeng Xing

Advanced Materials· Volume 35· Issue 22

Publisher page Open full text

Source abstract

Abstract

Immunotherapy In article 2212267, Haihua Xiao, Nianzeng Xing, and co-workers present a novel therapeutic strategy to achieve synergistic cancer immunotherapy via cuproptosis induced by reactive oxygen species (ROS)-responsive nanomedicine loaded with elesclomol and copper ([email protected]). With this approach, the tumor microenvironment is reprogrammed, and the expression of PD-L1 is increased, which consequently improves responsiveness of immunotherapy.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Cancer, Stress, Anesthesia, and Immune Response

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

Beijing National Laboratory for Molecular Sciences Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Department of Urology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University Taiyuan 030013 China

References

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