DataVXAdvanced MaterialsPaper
journal article·2021-04

Functional Skeletal Muscle Regeneration with Thermally Drawn Porous Fibers and Reprogrammed Muscle Progenitors for Volumetric Muscle Injury

Yoonhee Jin, Dena Shahriari, Eun Je Jeon, Seongjun Park, Yi Sun Choi, Jonghyeok Back, Hyungsuk Lee, Polina Anikeeva, Seung‐Woo Cho

Advanced Materials· Volume 33· Issue 14
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Source abstract

Abstract

Abstract Skeletal muscle has an inherent capacity for spontaneous regeneration. However, recovery after severe injuries such as volumetric muscle loss (VML) is limited. There is therefore a need to develop interventions to induce functional skeletal muscle restoration. One suggested approach includes tissue‐engineered muscle constructs. Tissue‐engineering treatments have so far been impeded by the lack of reliable cell sources and the challenges in engineering of suitable tissue scaffolds. To address these challenges, muscle extracellular matrix (MEM) and induced skeletal myogenic progenitor cells (iMPCs) are integrated within thermally drawn fiber based microchannel scaffolds. The microchannel fibers decorated with MEM enhance differentiation and maturation of iMPCs. Furthermore, engraftment of these bioengineered hybrid muscle constructs induce de novo muscle regeneration accompanied with microvessel and neuromuscular junction formation in a VML mouse model, ultimately leading to functional recovery of muscle activity.
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Research context

OpenAlex topics: Tissue Engineering and Regenerative Medicine · Electrospun Nanofibers in Biomedical Applications · Muscle Physiology and Disorders

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biotechnology Yonsei University Seoul 03722 Republic of Korea

Research Laboratory of Electronics Massachusetts Institute of Technology Cambridge MA 02139 USA

McGovern Institute for Brain Research Cambridge MA 02139 USA

Department of Biomaterials Science and Engineering Yonsei University Seoul 03722 Republic of Korea

Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

KAIST Institute for Health Science and Technology Daejeon 34141 Republic of Korea

School of Mechanical Engineering Yonsei University Seoul 03722 Republic of Korea

Department of Materials Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA

Department of Brain and Cognitive Sciences Massachusetts Institute of Technology Cambridge MA 02139 USA

Center for Nanomedicine Institute for Basic Science (IBS) Seoul 03722 Republic of Korea

Graduate Program of Nano Biomedical Engineering (NanoBME) Advanced Science Institute Yonsei University Seoul 03722 Republic of Korea

References (36)

Show source-provided references
1. 10.1097/01.prs.0000260595.85557.4110.1097/01.prs.0000260595.85557.41 ↗
2. 10.5435/00124635-201102001-0000710.5435/00124635-201102001-00007 ↗
3. 10.1016/j.injury.2008.08.03410.1016/j.injury.2008.08.034 ↗
4. 10.3928/01477447-20100526-2410.3928/01477447-20100526-24 ↗
5. 10.1002/jor.2273010.1002/jor.22730 ↗
6. 10.1016/j.biomaterials.2015.02.11010.1016/j.biomaterials.2015.02.110 ↗
7. 10.1016/j.addr.2014.08.01110.1016/j.addr.2014.08.011 ↗
8. 10.1155/2018/198487910.1155/2018/1984879 ↗
9. 10.1038/s41598-017-08232-210.1038/s41598-017-08232-2 ↗
10. 10.1093/ps/78.5.77810.1093/ps/78.5.778 ↗
11. 10.1007/s11626-003-0011-210.1007/s11626-003-0011-2 ↗
12. 10.1016/j.addr.2014.08.01110.1016/j.addr.2014.08.011 ↗
13. 10.1515/esp-2017-000510.1515/esp-2017-0005 ↗
14. 10.1016/j.ymeth.2015.03.00510.1016/j.ymeth.2015.03.005 ↗
15. 10.1111/vsu.1278710.1111/vsu.12787 ↗
16. 10.1007/s00441-014-2006-610.1007/s00441-014-2006-6 ↗
17. 10.1016/j.biomaterials.2016.07.02010.1016/j.biomaterials.2016.07.020 ↗
18. 10.1002/adma.20190202110.1002/adma.201902021 ↗
19. 10.1016/j.biomaterials.2008.03.03110.1016/j.biomaterials.2008.03.031 ↗
20. 10.1016/j.biomaterials.2013.07.05710.1016/j.biomaterials.2013.07.057 ↗
21. 10.1002/bab.4410.1002/bab.44 ↗
22. 10.1016/j.matbio.2013.03.00710.1016/j.matbio.2013.03.007 ↗
23. 10.1002/mus.2209410.1002/mus.22094 ↗
24. 10.1016/j.bbrc.2012.01.09110.1016/j.bbrc.2012.01.091 ↗
25. 10.1371/journal.pone.007202310.1371/journal.pone.0072023 ↗
26. 10.1089/ten.teb.2013.053410.1089/ten.teb.2013.0534 ↗
27. 10.1074/jbc.M30854220010.1074/jbc.M308542200 ↗
28. 10.1083/jcb.138.6.132310.1083/jcb.138.6.1323 ↗
29. 10.1083/jcb.20020203410.1083/jcb.200202034 ↗
30. 10.1002/adfm.20190386310.1002/adfm.201903863 ↗
31. 10.3389/fphys.2015.0030910.3389/fphys.2015.00309 ↗
32. 10.1038/s41467-020-14930-910.1038/s41467-020-14930-9 ↗
33. 10.1016/j.celrep.2018.03.09110.1016/j.celrep.2018.03.091 ↗
34. 10.1038/s41467-017-02636-410.1038/s41467-017-02636-4 ↗
35. 10.1038/s41536-020-0094-310.1038/s41536-020-0094-3 ↗
36. 10.1016/j.biomaterials.2015.11.06310.1016/j.biomaterials.2015.11.063 ↗