journal article·2023-04

Boosting Ferroptosis Therapy with Iridium Single‐Atom Nanocatalyst in Ultralow Metal Content

Junjie Cheng, Li Li, Duo Jin, Yi Dai, Yang Zhu, Jianhua Zou, Manman Liu, Wenxin Yu, Jiaji Yu, Yongfu Sun, Xiaoyuan Chen, Yangzhong Liu

Advanced Materials· Volume 35· Issue 17
Publisher page

Abstract

Abstract Nanocatalysts are promising tumor therapeutics due to their ability to induce reactive oxygen species in the tumor microenvironment. Although increasing metal loading can improve catalytic activity, the quandary of high metal content versus potential systemic biotoxicity remains challenging. Here, a fully exposed active site strategy by site‐specific anchoring of single iridium (Ir) atoms on the outer surface of a nitrogen‐doped carbon composite (Ir single‐atom catalyst (SAC)) is reported to achieve remarkable catalytic performance at ultralow metal content (≈0.11%). The Ir SAC exhibits prominent dual enzymatic activities to mimic peroxidase and glutathione peroxidase, which catalyzes the conversion of endogenous H2O2 into •OH in the acidic TME and depletes glutathione (GSH) simultaneously. With an advanced support of GSH‐trapping platinum(IV) and encapsulation with a red‐blood‐cell membrane, this nanocatalytic agent (Pt@IrSAC/RBC) causes intense lipid peroxidation that boosts tumor cell ferroptosis. The Pt@IrSAC/RBC demonstrates superior therapeutic efficacy in a mouse triple‐negative mammary carcinoma model, resulting in complete tumor ablation in a single treatment session with negligible side effects. These outcomes may provide valuable insights into the design of nanocatalysts with high performance and biosafety for biomedical applications.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry Center for Bioanalytical Chemistry University of Science and Technology of China Hefei 230026 P. R. China

Hefei National Research Center for Physical Sciences at Microscale University of Science and Technology of China Hefei 230026 P. R. China

College of Pharmaceutical Sciences Anhui Xinhua University Hefei 230001 P. R. China

Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore

Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore

Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive, Proteos Singapore 138673 Singapore

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · National University of Singapore · National Medical Research Council

References (68)

Show source-provided references
1. 10.1002/smll.20200446710.1002/smll.202004467 ↗
2. 10.1002/adma.20210705410.1002/adma.202107054 ↗
3. 10.1002/adma.20210122310.1002/adma.202101223 ↗
4. 10.1021/acsami.1c1270610.1021/acsami.1c12706 ↗
5. 10.1002/adhm.20220219810.1002/adhm.202202198 ↗
6. 10.1002/advs.20200077110.1002/advs.202000771 ↗
7. 10.1038/s41467-018-03903-810.1038/s41467-018-03903-8 ↗
8. 10.1002/smll.20220011610.1002/smll.202200116 ↗
9. 10.1021/acsnano.2c0807710.1021/acsnano.2c08077 ↗
10. 10.1038/s41467-020-19599-810.1038/s41467-020-19599-8 ↗
11. 10.1016/j.addr.2022.11464810.1016/j.addr.2022.114648 ↗
12. 10.1039/C8TA11416A10.1039/C8TA11416A ↗
13. 10.1002/adma.20180199510.1002/adma.201801995 ↗
14. 10.1039/C5SC00129C10.1039/C5SC00129C ↗
15. 10.1038/nmat244210.1038/nmat2442 ↗
16. 10.1039/C5TB00956A10.1039/C5TB00956A ↗
17. 10.1002/aenm.20200156110.1002/aenm.202001561 ↗
18. 10.1038/s41467-021-27640-710.1038/s41467-021-27640-7 ↗
19. 10.1021/acs.analchem.1c0466510.1021/acs.analchem.1c04665 ↗
20. 10.1021/ar300361m10.1021/ar300361m ↗
21. 10.1021/jacs.1c0468210.1021/jacs.1c04682 ↗
22. 10.1002/cssc.20180287310.1002/cssc.201802873 ↗
23. 10.1016/j.chempr.2018.12.01410.1016/j.chempr.2018.12.014 ↗
24. 10.1002/advs.20180058110.1002/advs.201800581 ↗
25. 10.1002/advs.20200437910.1002/advs.202004379 ↗
26. 10.1039/D0SC04576D10.1039/D0SC04576D ↗
27. 10.1021/acs.inorgchem.8b0165610.1021/acs.inorgchem.8b01656 ↗
28. 10.1002/adma.20220851210.1002/adma.202208512 ↗
29. 10.1002/anie.20190524110.1002/anie.201905241 ↗
30. 10.1002/adma.20170379810.1002/adma.201703798 ↗
31. 10.1038/s41467-017-01734-710.1038/s41467-017-01734-7 ↗
32. 10.1016/0041-008X(92)90273-U10.1016/0041-008X(92)90273-U ↗
33. 10.1002/med.2139110.1002/med.21391 ↗
34. 10.1002/anie.20050377810.1002/anie.200503778 ↗
35. 10.1038/ncomms142710.1038/ncomms1427 ↗
36. 10.1038/s41565-020-0665-x10.1038/s41565-020-0665-x ↗
37. 10.1002/anie.20190524110.1002/anie.201905241 ↗
38. 10.1080/10717544.2020.180344810.1080/10717544.2020.1803448 ↗
39. 10.1038/s41467-019-08731-y10.1038/s41467-019-08731-y ↗
40. 10.1002/anie.20220284310.1002/anie.202202843 ↗
41. Huo M. · ACS Nano · 2019 · 13 · 2643
42. 10.1039/C9SC00375D10.1039/C9SC00375D ↗
43. 10.3748/wjg.v4.i4.32610.3748/wjg.v4.i4.326 ↗
44. 10.1039/C5BM00048C10.1039/C5BM00048C ↗
45. 10.1021/jp064341w10.1021/jp064341w ↗
46. 10.1021/jacs.7b0426310.1021/jacs.7b04263 ↗
47. 10.1038/s41467-018-05798-x10.1038/s41467-018-05798-x ↗
48. 10.1038/s41467-021-24232-310.1038/s41467-021-24232-3 ↗
49. 10.1002/anie.20201715210.1002/anie.202017152 ↗
50. 10.1039/D0CC05422D10.1039/D0CC05422D ↗
51. 10.1038/nature0871010.1038/nature08710 ↗
52. 10.1080/15548627.2019.158625610.1080/15548627.2019.1586256 ↗
53. 10.7150/thno.5334610.7150/thno.53346 ↗
54. 10.1038/cr.2016.9510.1038/cr.2016.95 ↗
55. 10.15252/emmm.20170766110.15252/emmm.201707661 ↗
56. 10.1038/s41467-021-21714-210.1038/s41467-021-21714-2 ↗
57. 10.1016/j.celrep.2017.12.07710.1016/j.celrep.2017.12.077 ↗
58. 10.1016/j.cell.2013.12.01010.1016/j.cell.2013.12.010 ↗
59. 10.1002/anie.20210192410.1002/anie.202101924 ↗
60. 10.1021/acsnano.0c0062910.1021/acsnano.0c00629 ↗
61. 10.1080/17425247.2022.209385410.1080/17425247.2022.2093854 ↗
62. 10.1002/aic.1473510.1002/aic.14735 ↗
63. 10.1002/adma.20130063810.1002/adma.201300638 ↗
64. Yuan F. · Cancer Res. · 1995 · 55 · 3752
65. 10.1016/j.addr.2010.04.00910.1016/j.addr.2010.04.009 ↗
66. 10.1021/nn503779d10.1021/nn503779d ↗
67. 10.1002/adma.20180539110.1002/adma.201805391 ↗
68. 10.1002/adma.20220952910.1002/adma.202209529 ↗