DataVXAdvanced MaterialsPaper
journal article·2020-07

A Flexi‐PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy

Daniel Boon Loong Teh, Akshaya Bansal, Chou Chai, Tan Boon Toh, Robert Alan Jappy Tucker, Gil Gerald Lasam Gammad, Yanzhuang Yeo, Zhendong Lei, Xiang Zheng, Fengyuan Yang, John S. Ho, Nagarjun Bolem, Bing Cheng Wu, Muthu Kumar Gnanasammandhan, Lissa Hooi, Gavin Stewart Dawe, Camilo Libedinsky, Wei‐Yi Ong, Barry Halliwell, Edward Kai‐Hua Chow, Kah‐Leong Lim, Yong Zhang, Brian K. Kennedy

Advanced Materials· Volume 32· Issue 29
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Source abstract

Abstract

Abstract Near‐infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless‐based phototherapies by converting deep‐tissue‐penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep‐sited tumors. However, the retention of unsequestered UCNPs in tissue with minimal options for removal limits their clinical translation. To address this shortcoming, biocompatible UCNPs implants are developed to deliver upconversion photonic properties in a flexible, optical guide design. To enhance its translatability, the UCNPs implant is constructed with an FDA‐approved poly(ethylene glycol) diacrylate (PEGDA) core clad with fluorinated ethylene propylene (FEP). The emission spectrum of the UCNPs implant can be tuned to overlap with the absorption spectra of the clinically relevant photosensitizer, 5‐aminolevulinic acid (5‐ALA). The UCNPs implant can wirelessly transmit upconverted visible light till 8 cm in length and in a bendable manner even when implanted underneath the skin or scalp. With this system, it is demonstrated that NIR‐based chronic PDT is achievable in an untethered and noninvasive manner in a mouse xenograft glioblastoma multiforme (GBM) model. It is postulated that such encapsulated UCNPs implants represent a translational shift for wireless deep‐tissue phototherapy by enabling sequestration of UCNPs without compromising wireless deep‐tissue light delivery.
Source: crossref · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence Properties of Advanced Materials · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore Singapore 117456 Singapore

Department of Biomedical Engineering Faculty of Engineering National University of Singapore Singapore 117583 Singapore

Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Singapore 117456 Singapore

Lee Kong Chian School of Medicine Nanyang Technological University Singapore 308232 Singapore

The N.1 Institute for Health National University of Singapore Singapore 117599 Singapore

School of Biological Sciences Nanyang Technological University Singapore 637551 Singapore

NUS Graduate School for Integrative Sciences and Engineering National University of Singapore Singapore 117456 Singapore

Department of Electrical & Computer Engineering Faculty of Engineering National University of Singapore Singapore 117583 Singapore

Division of Neurosurgery National University Hospital Singapore 119228 Singapore

Department of Pathology National University Hospital Singapore 119228 Singapore

Cancer Science Institute of Singapore National University of Singapore Singapore 117599 Singapore

Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 117600 Singapore

Department of Psychology Faculty of Arts and Social Sciences National University of Singapore Singapore 117570 Singapore

Department of Anatomy Yong Loo Lin School of Medicine National University of Singapore Singapore 117594 Singapore

Center for Healthy Ageing National University Health System Singapore 119228 Singapore

Funding

National University of Singapore · Ministry of Education - Singapore · Lee Kong Chian School of Medicine, Nanyang Technological University

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