Enhancing Pharmacokinetics, Tumor Accumulation, and Antitumor Efficacy by Elastin‐Like Polypeptide Fusion of Interferon Alpha

Genetic fusion of elastin-like polypeptide (ELP) to the C-terminus of interferon alpha (IFN) generates a well-defined IFN-ELP fusion protein with high yield and well-retained bioactivity. The fusion protein significantly enhances pharmacokinetics, tumor accumulation, and antitumor efficacy of interferon alpha in a murine cancer model. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.