Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles
Source abstract
Abstract
Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Silicon Nanostructures and Photoluminescence · Advanced biosensing and bioanalysis techniques · Nanowire Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Materials Department of Bioengineering Institute of Biomedical Engineering Imperial College London SW7 2AZ London UK
Department of Surgery and Cancer Imperial College London W2 1PG London UK
Funding
FCT · Wellcome Trust · Wellcome Trust Senior Investigator · EPSRC · ERC Seventh Framework Programme Consolidator
References (27)
Show source-provided references
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