Targeted In Vivo Imaging of Microscopic Tumors with Ferritin‐based Nanoprobes Across Biological Barriers

The avascular microscopic breast and brain tumors (<1–2 mm diameter) can be noninvasively detected by designing human heavy-chain ferritin (HFn)-based nanoparticles as molecular probes for near-infrared fluorescence and magnetic resonance imaging. The intravenously injected HFn-based nano­particles (Cy5.5–HFn and M–HFn) can cross the endothelium, epithelium, and blood–brain barriers and be internalized into tumor cells. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.