DataVXAdvanced MaterialsPaper
journal article·2021-08

A Noninvasive Gut‐to‐Brain Oral Drug Delivery System for Treating Brain Tumors

Yang‐Bao Miao, Kuan‐Hung Chen, Chiung‐Tong Chen, Fwu‐Long Mi, Yu‐Jung Lin, Yen Chang, Chi‐Shiun Chiang, Jui‐To Wang, Kun‐Ju Lin, Hsing‐Wen Sung

Advanced Materials· Volume 33· Issue 34
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Source abstract

Abstract

Abstract Most orally administered drugs fail to reach the intracerebral regions because of the intestinal epithelial barrier (IEB) and the blood–brain barrier (BBB), which are located between the gut and the brain. Herein, an oral prodrug delivery system that can overcome both the IEB and the BBB noninvasively is developed for treating gliomas. The prodrug is prepared by conjugating an anticancer drug on β‐glucans using a disulfide‐containing linker. Following oral administration in glioma‐bearing mice, the as‐prepared prodrug can specifically target intestinal M cells, transpass the IEB, and be phagocytosed/hitchhiked by local macrophages (Mϕ). The Mϕ‐hitchhiked prodrug is transported to the circulatory system via the lymphatic system, crossing the BBB. The tumor‐overexpressed glutathione then cleaves the disulfide bond within the prodrug, releasing the active drug, improving its therapeutic efficacy. These findings reveal that the developed prodrug may serve as a gut‐to‐brain oral drug delivery platform for the well‐targeted treatment of gliomas.
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Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Glioma Diagnosis and Treatment

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters National Tsing Hua University Hsinchu 30013 Taiwan

Institute of Biotechnology and Pharmaceutical Research National Health Research Institutes Zhunan Miaoli 35053 Taiwan

Department of Biochemistry and Molecular Cell Biology School of Medicine College of Medicine Taipei Medical University Taipei 23142 Taiwan

Research Center for Applied Sciences Academia Sinica Taipei 11529 Taiwan

Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation and School of Medicine Tzu Chi University Hualien 97004 Taiwan

Department of Biomedical Engineering and Environmental Sciences National Tsing Hua University Hsinchu 30013 Taiwan

Neurological Institute Department of Neurosurgery Taipei Veterans General Hospital Taipei 11217 Taiwan

Institute of Brain Science National Yang‐Ming University Taipei 11221 Taiwan

Department of Nuclear Medicine and Molecular Imaging Center Linkou Chang Gung Memorial Hospital and Department of Medical Imaging and Radiological Sciences Chang Gung University Taoyuan 33302 Taiwan

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