DataVXAdvanced MaterialsPaper
journal article·2015-11

Mitochondrion‐Specific Live‐Cell Bioprobe Operated in a Fluorescence Turn‐On Manner and a Well‐Designed Photoactivatable Mechanism

Xinggui Gu, Engui Zhao, Jacky W. Y. Lam, Qian Peng, Yujun Xie, Yilin Zhang, Kam Sing Wong, Herman H. Y. Sung, Ian D. Williams, Ben Zhong Tang

Advanced Materials· Volume 27· Issue 44
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Source abstract

Abstract

A novel mitochondrion-specific live-cell fluorescence turn-on photoactivatable bioprobe, named o-TPP3M, is designed and readily prepared, operating in a new photoactivatable mechanism based on a twisted intramolecular charge-transfer effect, the restriction of intramolecular rotations, and photocyclodehydrogenation. This bioprobe exhibits unique photoactivation behavior, a large signal-to-background ratio, and no cytotoxicity to living cells, providing a promising candidate for varied bioresearch. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Research context

OpenAlex topics: Luminescence and Fluorescent Materials · Photoreceptor and optogenetics research · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

HKUST‐Shenzhen Research Institute No. 9 Yuexing 1st RD, South Area, Hi‐Tech Park Nanshan Shenzhen 518057 China

Departments of Chemistry, Physics, and Division of Life Science Institute of Molecular Functional Materials and Division of Biomedical Engineering The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong China

Key Laboratory of Organic Solids Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Guangdong Innovative Research Team SCUT‐HKUST Joint Research Laboratory State Key Laboratory of Luminescent Materials and Device South China University of Technology Guangzhou 51640 China

Funding

National Basic Research Program of China · University Grants Committee of Hong Kong · Research Grants Council of Hong Kong · Innovation and Technology Commission

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