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journal article·2024-06Open access

Synergistic Interaction between Metal Single‐Atoms and Defective WO3−x Nanosheets for Enhanced Sonodynamic Cancer Therapy

Zhan Zhou, Tao Wang, Tingting Hu, Hao Xu, Lin Cui, Baoli Xue, Xinshuo Zhao, Xiangrong Pan, Shilong Yu, Hai Li, Yong Qin, Jiankang Zhang, Lufang Ma, Ruizheng Liang, Chaoliang Tan

Advanced Materials· Volume 36· Issue 23
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Source abstract

Abstract

Abstract Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of metal SAs on oxygen vacancy (OV)‐rich WO3−x nanosheets to generate a synergistic effect for efficient SDT is reported. Crystalline WO3 and OV‐rich WO3−x nanosheets are first prepared by simple calcination of the WO3·H2O nanosheets under an air and N2 atmosphere, respectively. Pt, Cu, Fe, Co, and Ni metal SAs are then deposited on WO3−x nanosheets to obtain metal SA‐decorated WO3−x nanocomposites (M‐WO3−x). Importantly, the Cu‐WO3−x sonosensitizer exhibits a much higher activity for ultrasound (US)‐induced production of reactive oxygen species than that of the WO3−x and Cu SA‐decorated WO3, which is also higher than other M‐WO3−x nanosheets. Both the experimental and theoretical results suggest that the excellent SDT performance of the Cu‐WO3−x nanosheets should be attributed to the synergistic effect between Cu SAs and WO3−x OVs. Therefore, after polyethylene glycol modification, the Cu‐WO3−x can quickly kill cancer cells in vitro and effectively eradicate tumors in vivo under US irradiation. Transcriptome sequencing analysis and further molecular validation suggest that the Cu‐WO3−x‐mediated SDT‐activated apoptosis and TNF signaling pathways are potential drivers of tumor apoptosis induction.
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Research context

NanomaterialsMaterials processing

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Ultrasound and Hyperthermia Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Chemistry and Chemical Engineering Henan Key Laboratory of Function‐Oriented Porous Materials Luoyang Normal University Luoyang 471934 P. R. China

State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China

Department of Electrical and Electronic Engineering The University of Hong Kong Pokfulam Road Hong Kong SAR 999077 P. R. China

Interdisciplinary Research Center of Biology & Catalysis School of Life Sciences Northwestern Polytechnical University Xi'an 710072 P. R. China

School of Chemistry and Chemical Engineering Northwestern Polytechnical University Xi'an 710072 P. R. China

Institute of Advanced Materials (IAM) and Key Laboratory of Flexible Electronics (KLoFE) Nanjing Tech University (NanjingTech) 30 South Puzhu Road Nanjing 211816 P. R. China

State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Taiyuan 030001 P. R. China

Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou 324000 P. R. China

Funding

National Science Fund for Distinguished Young Scholars · National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities

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