journal article·2022-12

A Water‐Soluble AIEgen for Noninvasive Diagnosis of Kidney Fibrosis via SWIR Fluorescence and Photoacoustic Imaging

Dingyuan Yan, Tingting Li, Yilin Yang, Niu Niu, Deliang Wang, Jinyin Ge, Lei Wang, Ruiping Zhang, Dong Wang, Ben Zhong Tang

Advanced Materials· Volume 34· Issue 50
Publisher page

Abstract

Abstract Early diagnosis of renal fibrosis is crucially significant on account of its worldwide prevalent tendency. Optical imaging in the near‐infrared window has been recognized as an appealing technique for the timely detection of renal dysfunction. However, formulating a contrast agent that allows early monitoring of renal fibrosis and concurrently renally clearable in a normal group is still challenging. Herein, a nanosized fluorophore with aggregation‐induced emission (AIE) features, namely AIE‐4PEG550 NPs, is well‐tailored and amenable to longitudinal visualization of the fibrosis progression specifically in the early‐stage via short‐wave infrared (SWIR, 900–1700 nm) fluorescence and photoacoustic bimodal imaging. The small size (≈26 nm), renally filtrable molecular weight (3.3 kDa), high renal clearance efficiency (93.1 ± 1.7% excretion through the kidneys within 24 h), outstanding imaging performance, and good biocompatibility, together make AIE‐4PEG550 NPs remarkably impressive and far superior to clinical diagnostic assays. The finding in this study would provide a blueprint for the next generation of diagnostic agents for the extent of renal fibrosis.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Gold and Silver Nanoparticles Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for AIE Research Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional Materials College of Materials Science and Engineering Shenzhen University Shenzhen 518060 P. R. China

Department of Pharmacy School of Pharmacy Shanxi Medical University Taiyuan 030001 P. R. China

The Radiology Department of Third Hospital of Shanxi Medical University First Hospital of Shanxi Medical University Taiyuan 030000 P. R. China

School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen Guangdong 518172 P. R. China

Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemistry Institute of Molecular Functional Materials State Key Laboratory of Neuroscience Division of Biomedical Engineering and Division of Life Science The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong 999077 P. R. China

Funding

National Natural Science Foundation of China

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