Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma
Source abstract
Abstract
Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. A NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Glaucoma and retinal disorders · Retinal Diseases and Treatments · Nitric Oxide and Endothelin Effects
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Materials Department of Bioengineering and Institute of Biomedical Engineering Imperial College London London SW7 2AZ UK
Department of Bioengineering Imperial College London London SW7 2AZ UK
Department of Ophthalmology Duke University School of Medicine Durham NC 27710 USA
Department of Chemistry and iNANO Interdisciplinary Nanoscience Center Aarhus University Aarhus C 8000 Denmark
Funding
Fight for Sight UK · National Eye Institute · Rosetrees Trust · Engineering and Physical Sciences Research Council · Wellcome Trust
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