DataVXAdvanced MaterialsPaper
journal article·2018-07Open access

Enhanced Performance of a Molecular Photoacoustic Imaging Agent by Encapsulation in Mesoporous Silicon Nanoparticles

Jinyoung Kang, Dokyoung Kim, Junxin Wang, Yunho Han, Jonathan M. Zuidema, Ali Hariri, Ji‐Ho Park, Jesse V. Jokerst, Michael J. Sailor

Advanced Materials· Volume 30· Issue 27
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Source abstract

Abstract

Abstract Photoacoustic (PA) imaging allows visualization of the physiology and pathology of tissues with good spatial resolution and relatively deep tissue penetration. The method converts near‐infrared (NIR) laser excitation into thermal expansion, generating pressure transients that are detected with an acoustic transducer. Here, we find that the response of the PA contrast agent indocyanine green (ICG) can be enhanced 17‐fold when it is sealed within a rigid nanoparticle. ICG encapsulated in particles composed of porous silicon (pSiNP), porous silica, or calcium silicate all show greater PA contrast relative to equivalent quantities of free ICG, with the pSiNPs showing the strongest enhancement. A liposomal formulation of ICG performs similar to free ICG, suggesting that a rigid host nanostructure is necessary to enhance ICG performance. The improved response of the nanoparticle formulations is attributed to the low thermal conductivity of the porous inorganic hosts and their ability to protect the ICG payload from photolytic and/or thermal degradation. The translational potential of ICG‐loaded pSiNPs as photoacoustic probes is demonstrated via imaging of a whole mouse brain.
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Research context

Nanomaterials

OpenAlex topics: Photoacoustic and Ultrasonic Imaging · Nanoplatforms for cancer theranostics · Gas Sensing Nanomaterials and Sensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Nanoengineering University of California San Diego 9500 Gilman Drive La Jolla CA 92093 USA

Department of Anatomy and Neurobiology College of Medicine Center for Converging Humanities Kyung Hee University 26 Kyungheedae‐Ro Dongdaemun‐Gu Seoul 02447 Republic of Korea

Department of Bio and Brain Engineering & KAIST Institute for Health Science and Technology Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak‐ro Yuseong‐gu Daejeon 34141 Republic of Korea

Department of Chemistry and Biochemistry University of California San Diego 9500 Gilman Drive La Jolla CA 92093 USA

Department of Nanoengineering Materials Science and Engineering Program University of California San Diego 9500 Gilman Drive La Jolla CA 92093 USA

Department of Chemistry and Biochemistry Department of Nanoengineering Department of Bioengineering Materials Science and Engineering Program University of California San Diego La Jolla CA 92093 USA

Funding

Defense Advanced Research Projects Agency · National Science Foundation · National Institutes of Health · University of California, San Diego · National Research Foundation of Korea · Ministry of Education · Ministry of Science and Technology

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