journal article·2023-03Open access

Multifunctional 3D‐Printed Pollen Grain‐Inspired Hydrogel Microrobots for On‐Demand Anchoring and Cargo Delivery

Yun‐Woo Lee, Jae‐Kang Kim, Ugur Bozuyuk, Nihal Olcay Dogan, Muhammad Turab Ali Khan, Anitha Shiva, Anna‐Maria Wild, Metin Sitti

Advanced Materials· Volume 35· Issue 10

Abstract

Abstract While a majority of wireless microrobots have shown multi‐responsiveness to implement complex biomedical functions, their functional executions are strongly dependent on the range of stimulus inputs, which curtails their functional diversity. Furthermore, their responsive functions are coupled to each other, which results in the overlap of the task operations. Here, a 3D‐printed multifunctional microrobot inspired by pollen grains with three hydrogel components is demonstrated: iron platinum (FePt) nanoparticle‐embedded pentaerythritol triacrylate (PETA), poly N‐isopropylacrylamide (pNIPAM), and poly N‐isopropylacrylamide acrylic acid (pNIPAM‐AAc) structures. Each of these structures exhibits their respective targeted functions: responding to magnetic fields for torque‐driven surface rolling and steering, exhibiting temperature responsiveness for on‐demand surface attachment (anchoring), and pH‐responsive cargo release. The versatile multifunctional pollen grain‐inspired robots conceptualized here pave the way for various future medical microrobots to improve their projected performance and functional diversity.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Micro and Nano Robotics · Modular Robots and Swarm Intelligence · Advanced Materials and Mechanics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Physical Intelligence Department Max Planck Institute for Intelligent Systems 70569 Stuttgart Germany

Institute for Biomedical Engineering ETH Zurich Zurich 8092 Switzerland

School of Medicine and College of Engineering Koç University Istanbul 34450 Turkey

Funding

Max-Planck-Gesellschaft

References (69)

Show source-provided references
1. 10.1021/acsnano.0c0553010.1021/acsnano.0c05530 ↗
2. 10.1038/s41578-018-0022-y10.1038/s41578-018-0022-y ↗
3. 10.1002/adma.20130409810.1002/adma.201304098 ↗
4. 10.1002/adma.20160348310.1002/adma.201603483 ↗
5. 10.1038/nature2544310.1038/nature25443 ↗
6. 10.1126/sciadv.abc418910.1126/sciadv.abc4189 ↗
7. 10.1002/adma.20200355810.1002/adma.202003558 ↗
8. 10.1109/JPROC.2014.238510510.1109/JPROC.2014.2385105 ↗
9. 10.1002/adma.20200204710.1002/adma.202002047 ↗
10. 10.1126/scirobotics.aax061310.1126/scirobotics.aax0613 ↗
11. 10.1002/adma.20160507210.1002/adma.201605072 ↗
12. 10.1039/D0CS01062F10.1039/D0CS01062F ↗
13. 10.1126/sciadv.abe843610.1126/sciadv.abe8436 ↗
14. 10.1038/s41467-019-10549-710.1038/s41467-019-10549-7 ↗
15. 10.1126/sciadv.abf736410.1126/sciadv.abf7364 ↗
16. 10.1073/pnas.202209011810.1073/pnas.2022090118 ↗
17. 10.1002/smll.20220401610.1002/smll.202204016 ↗
18. 10.1109/TRO.2010.207303010.1109/TRO.2010.2073030 ↗
19. 10.1126/scirobotics.aat882910.1126/scirobotics.aat8829 ↗
20. 10.1002/adfm.20220727210.1002/adfm.202207272 ↗
21. 10.1002/adfm.20170722810.1002/adfm.201707228 ↗
22. 10.1126/scirobotics.aaz386710.1126/scirobotics.aaz3867 ↗
23. 10.1126/scirobotics.aba572610.1126/scirobotics.aba5726 ↗
24. 10.1038/s41563-019-0407-310.1038/s41563-019-0407-3 ↗
25. 10.1002/adfm.20210974110.1002/adfm.202109741 ↗
26. 10.1002/aisy.20200020410.1002/aisy.202000204 ↗
27. 10.1126/sciadv.abm913210.1126/sciadv.abm9132 ↗
28. 10.1038/nmat456910.1038/nmat4569 ↗
29. 10.1038/s41467-019-11141-910.1038/s41467-019-11141-9 ↗
30. 10.1021/acsnano.6b0410810.1021/acsnano.6b04108 ↗
31. 10.1021/acs.accounts.8b0028610.1021/acs.accounts.8b00286 ↗
32. 10.1126/scirobotics.abm142110.1126/scirobotics.abm1421 ↗
33. 10.1073/pnas.192009911710.1073/pnas.1920099117 ↗
34. 10.1002/admi.20180042510.1002/admi.201800425 ↗
35. 10.1146/annurev-bioeng-010510-10340910.1146/annurev-bioeng-010510-103409 ↗
36. 10.1002/adma.20210717710.1002/adma.202107177 ↗
37. 10.1088/2516-1091/ab22d510.1088/2516-1091/ab22d5 ↗
38. 10.1038/s41557-020-0444-110.1038/s41557-020-0444-1 ↗
39. 10.1016/j.apmt.2018.09.01610.1016/j.apmt.2018.09.016 ↗
40. 10.1021/acsami.0c1822110.1021/acsami.0c18221 ↗
41. 10.1126/scirobotics.abe185810.1126/scirobotics.abe1858 ↗
42. 10.1002/adma.20210932510.1002/adma.202109325 ↗
43. Ma Z. · Stem Cells Int · 2022 · 377 · 751
44. 10.1002/smll.20080116110.1002/smll.200801161 ↗
45. 10.1126/sciadv.aau153210.1126/sciadv.aau1532 ↗
46. 10.1038/s41467-018-06491-910.1038/s41467-018-06491-9 ↗
47. 10.1126/scitranslmed.aaw332910.1126/scitranslmed.aaw3329 ↗
48. 10.1038/nature2238210.1038/nature22382 ↗
49. 10.1002/adfm.20190328010.1002/adfm.201903280 ↗
50. 10.1002/adma.20200049710.1002/adma.202000497 ↗
51. 10.1002/adfm.20200011210.1002/adfm.202000112 ↗
52. 10.1002/smll.20150086010.1002/smll.201500860 ↗
53. 10.1002/smll.20190670110.1002/smll.201906701 ↗
54. 10.1021/acsami.9b0481710.1021/acsami.9b04817 ↗
55. 10.1038/s41467-019-09372-x10.1038/s41467-019-09372-x ↗
56. 10.1002/adma.20220188810.1002/adma.202201888 ↗
57. 10.1021/acsami.0c1431410.1021/acsami.0c14314 ↗
58. 10.1038/s41467-018-08175-w10.1038/s41467-018-08175-w ↗
59. 10.1038/s41563-022-01258-610.1038/s41563-022-01258-6 ↗
60. 10.1038/nmat454410.1038/nmat4544 ↗
61. 10.1021/am508621s10.1021/am508621s ↗
62. 10.1038/nature0502410.1038/nature05024 ↗
63. 10.1088/0964-1726/15/6/03110.1088/0964-1726/15/6/031 ↗
64. 10.1021/jp201826v10.1021/jp201826v ↗
65. 10.1088/0964-1726/23/9/09400810.1088/0964-1726/23/9/094008 ↗
66. 10.1126/sciadv.abn343110.1126/sciadv.abn3431 ↗
67. 10.1126/sciadv.160146910.1126/sciadv.1601469 ↗
68. 10.1126/sciadv.abh027310.1126/sciadv.abh0273 ↗
69. 10.3389/fphys.2019.0132910.3389/fphys.2019.01329 ↗