DataVXAdvanced MaterialsPaper
journal article·2021-01

Imaging Cellular Aerobic Glycolysis using Carbon Dots for Early Warning of Tumorigenesis

Jipeng Li, Siwei Yang, Zeyang Liu, Gang Wang, Peng He, Wei Wei, Muyue Yang, Yuan Deng, Ping Gu, Xiaoming Xie, Zhenhui Kang, Guqiao Ding, Huifang Zhou, Xianqun Fan

Advanced Materials· Volume 33· Issue 1
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Source abstract

Abstract

Abstract Early warning of tumor formation is crucial for the classification, treatment, and prognosis of tumor patients. Here, a new strategy is reported, aimed at realizing this goal based on imaging aerobic glycolysis processes using nitrogen‐doped carbon dots (N‐CDs) as fluorescent probes. The intensity of the photoluminescence emitted by the N‐CDs is specifically enhanced by nicotinamide adenine dinucleotide (NAD+, oxidized) in the physiological environment. The N‐CDs allow a few (five to ten) abnormal cells in spontaneous hepatocellular carcinoma models to be identified before the in situ development of tumor tissue. The N‐CD probes can also distinguish tumor cells from normal cells and be used to evaluate their proliferation activity (with a specificity of up to 96.15% in 13 types of tumor cells and 90.90% in orthotopic xenograft models). The N‐CDs are successfully used to monitor the invasion of tumor cells into neighboring tissues and body fluids in 49 clinical samples (with a sensitivity up to 79.31%). These included three vitreous body samples (from patients with retinoblastoma), 42 urine samples (22 patients clinically diagnosed with urothelium carcinoma and 20 healthy persons), and four hydrothorax samples (from patients with metastatic lesions).
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques · Carbon and Quantum Dots Applications

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Affiliations

Department of Ophthalmology Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai 200011 China

Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai Ninth People's Hospital Shanghai 200011 China

State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information Technology (SIMIT) Chinese Academy of Science Shanghai 200500 China

College of Materials Science and Opto‐Electronic Technology University of Chinese Academy of Sciences Beijing 100049 P. R. China

Department of Microelectronic Science and Engineering School of Physical Science and Technology Ningbo University Ningbo 315211 P. R. China

Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon‐based Functional Materials and Devices Soochow University Suzhou 215123 China

Institute of Advanced Materials Northeast Normal University Changchun 130024 China

Funding

National Natural Science Foundation of China · Innovationsfonden · Collaborative Innovation Center of Suzhou Nano Science and Technology · Priority Academic Program Development of Jiangsu Higher Education Institutions · Higher Education Discipline Innovation Project

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