DataVXAdvanced MaterialsPaper
journal article·2020-10Open access

An Antioxidant Enzyme Therapeutic for COVID‐19

Meng Qin, Zheng Cao, Jing Wen, Qingsong Yu, Chaoyong Liu, Fang Wang, Jianjun Zhang, Fengmei Yang, Yanyan Li, Gregory Fishbein, Sen Yan, Bin Xu, Yi Hou, Zhenbo Ning, Kaili Nie, Ni Jiang, Zhen Liu, Jun Wu, Yanting Yu, Heng Li, Huiwen Zheng, Jing Li, Weihua Jin, Shen Pang, Shuai Wang, Jianfeng Chen, Zhihua Gan, Zhanlong He, Yunfeng Lu

Advanced Materials· Volume 32· Issue 43
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Source abstract

Abstract

Abstract The COVID‐19 pandemic has taken a significant toll on people worldwide, and there are currently no specific antivirus drugs or vaccines. Herein it is a therapeutic based on catalase, an antioxidant enzyme that can effectively breakdown hydrogen peroxide and minimize the downstream reactive oxygen species, which are excessively produced resulting from the infection and inflammatory process, is reported. Catalase assists to regulate production of cytokines, protect oxidative injury, and repress replication of SARS‐CoV‐2, as demonstrated in human leukocytes and alveolar epithelial cells, and rhesus macaques, without noticeable toxicity. Such a therapeutic can be readily manufactured at low cost as a potential treatment for COVID‐19.
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Research context

OpenAlex topics: Vitamin C and Antioxidants Research · COVID-19 Clinical Research Studies · Tryptophan and brain disorders

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Organic‐inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical Technology Beijing 100029 China

Department of Chemical and Biomolecular Engineering Microbiology, Immunology and Molecular Genetics, and the David Geffen School of Medicine University of California, Los Angeles Los Angeles CA 90095 USA

Institute of Medical Biology Chinese Academy of Medical Sciences Peking Union Medical College Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease Kunming 650118 China

Guangdong‐Hongkong‐Macau Institute of CNS Regeneration Jinan University Guangdong 510632 China

Vivibaba, Inc University of California 570 Westwood Plaza Los Angeles CA 90095 USA

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