journal article·2023-07Open access

pH‐Triggered Size‐Transformable and Bioactivity‐Switchable Self‐Assembling Chimeric Peptide Nanoassemblies for Combating Drug‐Resistant Bacteria and Biofilms

Peng Tan, Chenchen Wu, Qi Tang, Tao Wang, Chenlong Zhou, Yakun Ding, Huiyang Fu, Shenrui Xu, Yuqing Feng, Yucheng Zhang, Qing Dai, Xi Ma

Advanced Materials· Volume 35· Issue 29

Abstract

Abstract Drug‐resistant bacteria and biofilm‐associated infections are prominent problems in the field of antibacterial medicine, seriously affecting human and animal health. Despite the great potential of nanomaterials in the antibacterial field, overcoming the paradox of size and charge, efficient penetration, and retention within biofilms remain a formidable challenge. Here, self‐assembling chimeric peptide nanoassemblies composed of multiple functional fragments are designed for the treatment of drug‐resistant bacteria and biofilm‐associated infections. Notably, the chimeric peptide self‐assembles into nanofibers at pH 7.4 and is transformable into nanoparticles in the acidic biofilm‐infected microenvironment at pH 5.0, and thus achieves a size reduction and charge increase, improving the penetration into the bacterial biofilms and killing drug‐resistant bacteria by a mechanism dominated by membrane cleavage. In vivo mouse and piglet infection models confirm the ability of chimeric peptide nanoassemblies to reduce bacterial load within biofilms. Collectively, this research on pathological‐environment‐driven nanostructural transformations may provide a theoretical basis for designing high‐performance antibacterial nanomaterials and advance the application of peptide‐based nanomaterials in medicine and animal husbandry.
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Research context

OpenAlex topics: Antimicrobial Peptides and Activities · Supramolecular Self-Assembly in Materials · Bacteriophages and microbial interactions

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Beijing 100193 China

CAS Key Laboratory of Nanophotonic Materials and Devices CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China

Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China

Luoyang Key Laboratory of Animal Genetic and Breeding College of Animal Science Henan University of Science and Technology Luoyang 471003 China

Henan International Joint Laboratory of Crop Gene Resource and Improvements School of Agricultural Sciences Zhengzhou University Zhengzhou 450001 China

Key Laboratory of Innovative Utilization of Local Cattle and Sheep Germplasm Resources (Co‐construction by Ministry and Province) Ministry of Agriculture and Rural Affairs Zhengzhou University Zhengzhou 450001 China

Funding

National Natural Science Foundation of China · Higher Education Discipline Innovation Project

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