DataVXAdvanced MaterialsPaper
journal article·2023-06Open access

Impairing Tumor Metabolic Plasticity via a Stable Metal‐Phenolic‐Based Polymeric Nanomedicine to Suppress Colorectal Cancer

Xiaoling Li, Zhenyu Duan, Xiaoting Chen, Dayi Pan, Qiang Luo, Lei Gu, Gang Xu, Yinggang Li, Hu Zhang, Qiyong Gong, Rongjun Chen, Zhongwei Gu, Kui Luo

Advanced Materials· Volume 35· Issue 23
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Source abstract

Abstract

Abstract Targeting metabolic vulnerability of tumor cells is a promising anticancer strategy. However, the therapeutic efficacy of existing metabolism‐regulating agents is often compromised due to tolerance resulting from tumor metabolic plasticity, as well as their poor bioavailability and tumor‐targetability. Inspired by the inhibitive effect of N‐ethylmaleimide on the mitochondrial function, a dendronized‐polymer‐functionalized metal‐phenolic nanomedicine (pOEG‐b‐D‐SH@NP) encapsulating maleimide‐modified doxorubicin (Mal‐DOX) is developed to enable improvement in the overall delivery efficiency and inhibition of the tumor metabolism via multiple pathways. It is observed that Mal‐DOX and its derived nanomedicine induces energy depletion of CT26 colorectal cancer cells more efficiently than doxorubicin, and shifts the balance of programmed cell death from apoptosis toward necroptosis. Notably, pOEG‐b‐D‐SH@NP simultaneously inhibits cellular oxidative phosphorylation and glycolysis, thus potently suppressing cancer growth and peritoneal intestinal metastasis in mouse models. Overall, the study provides a promising dendronized‐polymer‐derived nanoplatform for the treatment of cancers through impairing metabolic plasticity.
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Research context

PolymersNanomaterials

OpenAlex topics: Cancer, Hypoxia, and Metabolism · Nanoplatforms for cancer theranostics · Metabolomics and Mass Spectrometry Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Huaxi MR Research Center (HMRRC) Animal Experimental Center Department of Radiology National Clinical Research Center for Geriatrics Frontiers Science Center for Disease‐Related Molecular Network State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China

Functional and molecular imaging Key Laboratory of Sichuan Province Key Laboratory of Transplant Engineering and Immunology, NHC, and Research Unit of Psychoradiology Chinese Academy of Medical Sciences Chengdu 610041 China

Amgen Bioprocessing Centre Keck Graduate Institute Claremont CA 91711 USA

Department of Radiology West China Xiamen Hospital of Sichuan University Xiamen Fujian 361000 China

Department of Chemical Engineering Imperial College London South Kensington Campus London SW7 2AZ UK

Funding

National Natural Science Foundation of China · National Basic Research Program of China · West China Hospital, Sichuan University · China Postdoctoral Science Foundation

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