journal article·2021-04

Biologically Excretable Aggregation‐Induced Emission Dots for Visualizing Through the Marmosets Intravitally: Horizons in Future Clinical Nanomedicine

Zhe Feng, Siyi Bai, Ji Qi, Chaowei Sun, Yuhuang Zhang, Xiaoming Yu, Huwei Ni, Di Wu, Xiaoxiao Fan, Dingwei Xue, Shunjie Liu, Ming Chen, Junyi Gong, Peifa Wei, Mubin He, Jacky W. Y. Lam, Xinjian Li, Ben Zhong Tang, Lixia Gao, Jun Qian

Advanced Materials· Volume 33· Issue 17
Publisher page

Abstract

Abstract Superb reliability and biocompatibility equip aggregation‐induced emission (AIE) dots with tremendous potential for fluorescence bioimaging. However, there is still a chronic lack of design instructions of excretable and bright AIE emitters. Here, a kind of PEGylated AIE (OTPA‐BBT) dots with strong absorption and extremely high second near‐infrared region (NIR‐II) PLQY of 13.6% is designed, and a long‐aliphatic‐chain design blueprint contributing to their excretion from an animal's body is proposed. Assisted by the OTPA‐BBT dots with bright fluorescence beyond 1100 nm and even 1500 nm (NIR‐IIb), large‐depth cerebral vasculature (beyond 600 µm) as well as real‐time blood flow are monitored through a thinned skull, and noninvasive NIR‐IIb imaging with rich high‐spatial‐frequency information gives a precise presentation of gastrointestinal tract in marmosets. Importantly, after intravenous or oral administration, the definite excretion of OTPA‐BBT dots from the body is demonstrated, which provides influential evidence of biosafety.
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Research context

OpenAlex topics: Luminescence and Fluorescent Materials · Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic Research College of Optical Science and Engineering International Research Center for Advanced Photonics Zhejiang University Hangzhou 310058 China

Department of Neurology of the Second Affiliated Hospital Interdisciplinary Institute of Neuroscience and Technology Zhejiang University School of Medicine Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering and Instrument Science Zhejiang University Hangzhou 310027 China

Department of Chemistry The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Institute for Advanced Study and Department of Chemical and Biological Engineering and Institute of Molecular Functional Materials The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong 999077 China

Women's Hospital Zhejiang University School of Medicine Hangzhou 310006 China

Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou 310016 China

Funding

National Natural Science Foundation of China · National Basic Research Program of China · Fundamental Research Funds for the Central Universities · Innovation and Technology Commission

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