journal article·2024-02

Hydrophobic Cross‐Linked Chains Regulate High Wet Tissue Adhesion Hydrogel with Toughness, Anti‐hydration for Dynamic Tissue Repair

Heng An, Meng Zhang, Zhe Huang, Yongxiang Xu, Shen Ji, Zhen Gu, Peixun Zhang, Yongqiang Wen

Advanced Materials· Volume 36· Issue 8
Publisher page

Abstract

Abstract Hydrogel adhesion materials are widely reported for tissue engineering repair applications, however, wet tissue surface moisture can reduce the wet‐adhesion properties and mechanical strength of hydrogels limiting their application. Here, anti‐hydration gelatin–acrylic acid–ethylene dimethacrylate (GAE) hydrogels with hydrophobic cross‐linked chains are constructed. The prepared GAE hydrogel is soaked in PBS (3 days) with a volume change of 0.6 times of the original and the adhesive strength, Young's modulus, toughness, and burst pressure are maintained by ≈70% of the original. A simple and universal method is used to introduce hydrophobic chains as cross‐linking points to prepare hydrogels with anti‐hydration, toughness, and high wet state adhesion. The hydrophobic cross‐linked chains not only restrict the movement of molecular chains but also hinder the intrusion of water molecules. Antihydration GAE hydrogels exhibit good biocompatibility, slow drug release, and dynamic oral wet‐state tissue repair properties. Therefore, the anti‐hydration hydrogel has excellent toughness, wet tissue adhesion properties, and good prospects for biological applications.
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Research context

OpenAlex topics: Surgical Sutures and Adhesives · Polymer Surface Interaction Studies · Hydrogels: synthesis, properties, applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing Key Laboratory for Bioengineering and Sensing Technology Daxing Research Institute School of Chemistry and Biological Engineering University of Science and Technology Beijing Beijing 100083 China

Department of Orthopedics and Trauma Peking University People’s Hospital, Key Laboratory of Trauma and Neural Regeneration, Peking University, National Center for Trauma Medicine Qingdao Hospital, Peking University People's Hospital Beijing 100044 China

Department of Dental Materials Peking University School and Hospital of Stomatology & National Center ofStomatology & National Clinical Research Center for Oral Diseases & NationalEngineering Laboratory for Digital and Material Technology of Stomatology & BeijingKey Laboratory of Digital Stomatology & Research Center of Engineering and‐ 3 ‐Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratoryfor Dental Materials Beijing 100081 China

State Key Laboratory of Membrane Biology, Institute of Zoology Chinese Academy of Sciences Chaoyang District Beijing 100101 China

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities

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