journal article·2017-09Open access

A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer

Yanyan Hu, Chongwei Chi, Shunhao Wang, Lingxiong Wang, Ping Liang, Fangyi Liu, Wenting Shang, Weiwei Wang, Fengrong Zhang, Shanshan Li, Heyun Shen, Xiaoling Yu, Huiyu Liu, Jie Tian

Advanced Materials· Volume 29· Issue 33

Abstract

Although nanoparticle‐based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine‐125 (125I) interstitial brachytherapy (IBT‐125‐I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti‐urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT‐125‐I, a 25% higher median survival rate of IPTT with complete ablation by one‐time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer Research and Treatments · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Interventional Ultrasound General Hospital of People's Liberation Army Beijing 100853 China

Key Laboratory of Molecular Imaging Institute of Automation Chinese Academy of Sciences Beijing 100190 China

Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess State Key Laboratory of Chemical Resource Engineering Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 China

State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco‐Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

University of Chinese Academy of Sciences Beijing 100049 China

Cancer Center lab Division of Internal Medicine General Hospital of People's Liberation Army Beijing 100853 China

Funding

National Natural Science Foundation of China · Chinese Academy of Sciences

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