Engineering and Targeting Neutrophils for Cancer Therapy
Source abstract
Abstract
Abstract Neutrophils are the most abundant white blood cells in the circulation and act as the first line of defense against infections. Increasing evidence suggests that neutrophils possess heterogeneous phenotypes and functional plasticity in human health and diseases, including cancer. Neutrophils play multifaceted roles in cancer development and progression, and an N1/N2 paradigm of neutrophils in cancer is proposed, where N1 neutrophils exert anti‐tumor properties while N2 neutrophils display tumor‐supportive and immune‐suppressive functions. Selective activation of beneficial neutrophil population and targeted inhibition or re‐polarization of tumor‐promoting neutrophils has shown an important potential in tumor therapy. In addition, due to the natural inflammation‐responsive and physical barrier‐crossing abilities, neutrophils and their derivatives (membranes and extracellular vesicles (EVs)) are regarded as advanced drug delivery carriers for enhanced tumor targeting and improved therapeutic efficacy. In this review, the recent advances in engineering neutrophils for drug delivery and targeting neutrophils for remodeling tumor microenvironment (TME) are comprehensively presented. This review will provide a broad understanding of the potential of neutrophils in cancer therapy.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Neutrophil, Myeloperoxidase and Oxidative Mechanisms · Immune cells in cancer · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Jiangsu Key Laboratory of Medical Science and Laboratory Medicine School of Medicine Jiangsu University Zhenjiang Jiangsu 212013 China
Departmemt of Clinical Laboratory Medicine Affiliated Tumor Hospital of Nantong University Nantong Jiangsu 226361 China
Department of Radiation Oncology Jiangsu University Cancer Institute Affiliated Hospital of Jiangsu University Zhenjiang Jiangsu 212001 China
School of Chemistry and Chemical Engineering Jiangsu University Zhenjiang Jiangsu 212013 China
Department of Biomaterials and Biomedical Technology University Medical Center Groningen/University of Groningen Ant. Deusinglaan 1 Groningen 9713 AV Netherlands
W.J. Kolff Institute for Biomedical Engineering and Materials Science University Medical Center Groningen University of Groningen Ant. Deusinglaan 1 Groningen 9713 AV Netherlands
Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki Helsinki FI‐00014 Finland
Pharmaceutical Sciences Laboratory Abo Akademi University Turku 20520 Finland
Turku Bioscience Centre University of Turku and Abo Akademi University Turku 20520 Finland
Funding
National Natural Science Foundation of China · Academy of Finland · Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta
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