Beyond Photo: Xdynamic Therapies in Fighting Cancer
Source abstract
Abstract
Abstract Reactive oxygen species (ROS)‐related therapeutic approaches are developed as a promising modality for cancer treatment because the aberrant increase of intracellular ROS level can cause cell death due to nonspecific oxidation damage to key cellular biomolecules. However, the most widely considered strategy, photodynamic therapy (PDT), suffers from critical limitations such as limited tissue‐penetration depth, high oxygen dependence, and phototoxicity. Non‐photo‐induced ROS generation strategies, which are defined as Xdynamic therapies (X = sono, radio, microwave, chemo, thermo, and electro), show good potential to overcome the drawbacks of PDT. Herein, recent advances in the development of Xdynamic therapies, including the design of systems, the working mechanisms, and examples of cancer therapy application, are introduced. Furthermore, the approaches to enhance treatment efficiency of Xdynamic therapy are highlighted. Finally, the perspectives and challenges of these strategies are also discussed.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Photoacoustic and Ultrasonic Imaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Life Sciences Tianjin University Tianjin 300072 China
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China
Departments of Diagnostic Radiology and Surgery Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore
Departments of Chemical and Biomolecular Engineering, and Biomedical Engineering Faculty of Engineering National University of Singapore Singapore 117597 Singapore
Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore
Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore
Funding
National Natural Science Foundation of China · Young Elite Scientists Sponsorship Program by Tianjin · National University of Singapore
References (100+)
Show source-provided references
1. 10.1038/nrm225610.1038/nrm2256 ↗
2. 10.1039/C6CS00271D10.1039/C6CS00271D ↗
3. 10.1073/pnas.050036710210.1073/pnas.0500367102 ↗
4. 10.1021/acs.chemrev.8b0062610.1021/acs.chemrev.8b00626 ↗
5. 10.1021/cr500419810.1021/cr5004198 ↗
6. 10.7150/thno.1954610.7150/thno.19546 ↗
7. 10.1002/smll.20170281510.1002/smll.201702815 ↗
8. 10.1002/adma.20180274810.1002/adma.201802748 ↗
9. 10.1021/am500097f10.1021/am500097f ↗
10. 10.1002/anie.20180881110.1002/anie.201808811 ↗
11. 10.1002/anie.20190327710.1002/anie.201903277 ↗
12. 10.1021/acsnano.9b0721210.1021/acsnano.9b07212 ↗
13. 10.1039/C8CC04653K10.1039/C8CC04653K ↗
14. 10.1021/acsnano.7b0350710.1021/acsnano.7b03507 ↗
15. 10.1021/acsnano.8b0834610.1021/acsnano.8b08346 ↗
16. 10.31635/ccschem.019.2018003310.31635/ccschem.019.20180033 ↗
17. 10.1021/cr400532z10.1021/cr400532z ↗
18. 10.3171/2013.7.JNS1341510.3171/2013.7.JNS13415 ↗
19. 10.1016/j.pdpdt.2012.01.00110.1016/j.pdpdt.2012.01.001 ↗
20. 10.1016/j.bjoms.2012.11.01110.1016/j.bjoms.2012.11.011 ↗
21. Kostovic K. · Coll. Antropol. · 2012 · 36 · 1477
22. 10.1001/jamaoto.2013.338710.1001/jamaoto.2013.3387 ↗
23. 10.1002/adma.20180247910.1002/adma.201802479 ↗
24. 10.1021/acsnano.5b0450110.1021/acsnano.5b04501 ↗
25. 10.1039/C5BM00328H10.1039/C5BM00328H ↗
26. 10.1039/C4CC08178A10.1039/C4CC08178A ↗
27. 10.1002/anie.20190261210.1002/anie.201902612 ↗
28. 10.1002/adma.20190189310.1002/adma.201901893 ↗
29. 10.1002/adma.20180644410.1002/adma.201806444 ↗
30. 10.1002/advs.20170084710.1002/advs.201700847 ↗
31. 10.1002/advs.20190084810.1002/advs.201900848 ↗
32. 10.1002/anie.20200944210.1002/anie.202009442 ↗
33. 10.1016/j.matt.2019.03.00710.1016/j.matt.2019.03.007 ↗
34. 10.1021/cr400425h10.1021/cr400425h ↗
35. 10.1039/C4CS00158C10.1039/C4CS00158C ↗
36. 10.1039/C4CS00011K10.1039/C4CS00011K ↗
37. 10.1021/acsnano.8b0839810.1021/acsnano.8b08398 ↗
38. 10.1021/acsnano.8b0313810.1021/acsnano.8b03138 ↗
39. 10.1021/acsnano.9b0516910.1021/acsnano.9b05169 ↗
40. 10.1002/anie.20180513810.1002/anie.201805138 ↗
41. 10.31635/ccschem.019.2019001010.31635/ccschem.019.20190010 ↗
42. 10.1021/jacs.7b0555910.1021/jacs.7b05559 ↗
43. 10.1002/adma.20180200610.1002/adma.201802006 ↗
44. 10.1016/j.matt.2020.02.01310.1016/j.matt.2020.02.013 ↗
45. 10.7150/thno.4622810.7150/thno.46228 ↗
46. 10.1002/adma.20160669010.1002/adma.201606690 ↗
47. 10.1002/adma.20180121610.1002/adma.201801216 ↗
48. 10.1039/D0TB00609B10.1039/D0TB00609B ↗
49. 10.1038/nrd166210.1038/nrd1662 ↗
50. 10.1007/s11427-017-9262-x10.1007/s11427-017-9262-x ↗
51. 10.1002/adma.20160201210.1002/adma.201602012 ↗
52. 10.1039/C7CS00525C10.1039/C7CS00525C ↗
53. 10.7150/thno.1671510.7150/thno.16715 ↗
54. 10.1038/srep2320010.1038/srep23200 ↗
55. 10.1039/C7TB00938K10.1039/C7TB00938K ↗
56. 10.1002/advs.20180117510.1002/advs.201801175 ↗
57. 10.1021/jz500770c10.1021/jz500770c ↗
58. 10.1021/acsnano.8b0089910.1021/acsnano.8b00899 ↗
59. 10.1021/acs.nanolett.6b0254710.1021/acs.nanolett.6b02547 ↗
60. 10.1021/acsnano.7b0521510.1021/acsnano.7b05215 ↗
61. 10.1002/adfm.20190859810.1002/adfm.201908598 ↗
62. 10.1002/adfm.20180576410.1002/adfm.201805764 ↗
63. 10.1002/smll.20180402810.1002/smll.201804028 ↗
64. 10.7150/thno.2956910.7150/thno.29569 ↗
65. 10.1007/s12274-017-1719-810.1007/s12274-017-1719-8 ↗
66. 10.1016/j.biomaterials.2019.11925110.1016/j.biomaterials.2019.119251 ↗
67. 10.1002/adhm.20190072010.1002/adhm.201900720 ↗
68. 10.1021/acsami.8b2196810.1021/acsami.8b21968 ↗
69. 10.1016/j.ejpb.2019.12.00510.1016/j.ejpb.2019.12.005 ↗
70. 10.1016/j.ultras.2015.10.00810.1016/j.ultras.2015.10.008 ↗
71. 10.1016/j.ultsonch.2005.10.00110.1016/j.ultsonch.2005.10.001 ↗
72. 10.1016/j.ultras.2010.11.00510.1016/j.ultras.2010.11.005 ↗
73. 10.1039/C8NH00276B10.1039/C8NH00276B ↗
74. 10.1016/j.ultsonch.2017.03.01910.1016/j.ultsonch.2017.03.019 ↗
75. 10.1021/jacs.6b1184610.1021/jacs.6b11846 ↗
76. 10.7150/thno.3191810.7150/thno.31918 ↗
77. 10.1016/j.matt.2019.08.02210.1016/j.matt.2019.08.022 ↗
78. 10.1016/j.biomaterials.2020.12023910.1016/j.biomaterials.2020.120239 ↗
79. 10.1002/adfm.20190892410.1002/adfm.201908924 ↗
80. 10.1002/adma.20180018010.1002/adma.201800180 ↗
81. 10.7150/thno.4157810.7150/thno.41578 ↗
82. 10.1039/C8CS00921J10.1039/C8CS00921J ↗
83. 10.1021/nl504044p10.1021/nl504044p ↗
84. 10.1002/anie.20190871210.1002/anie.201908712 ↗
85. 10.1002/adfm.20170749610.1002/adfm.201707496 ↗
86. 10.1002/adma.20180802410.1002/adma.201808024 ↗
87. 10.1021/ja500671h10.1021/ja500671h ↗
88. 10.1038/s41551-018-0203-410.1038/s41551-018-0203-4 ↗
89. 10.1021/jacs.8b1159310.1021/jacs.8b11593 ↗
90. 10.1002/anie.20170482810.1002/anie.201704828 ↗
91. 10.1021/acs.nanolett.9b0368210.1021/acs.nanolett.9b03682 ↗
92. 10.1021/acsnano.8b0774910.1021/acsnano.8b07749 ↗
93. 10.1016/j.biomaterials.2020.11977310.1016/j.biomaterials.2020.119773 ↗
94. 10.1039/C8BM00142A10.1039/C8BM00142A ↗
95. 10.1039/C8NR03927E10.1039/C8NR03927E ↗
96. 10.1021/acs.nanolett.9b0173510.1021/acs.nanolett.9b01735 ↗
97. 10.1021/acsnano.7b0886810.1021/acsnano.7b08868 ↗
98. 10.1039/C9CC07762F10.1039/C9CC07762F ↗
99. 10.1002/anie.20180566410.1002/anie.201805664 ↗
100. 10.1021/acsnano.7b0685210.1021/acsnano.7b06852 ↗