Starvation, Ferroptosis, and Prodrug Therapy Synergistically Enabled by a Cytochrome c Oxidase like Nanozyme
Source abstract
Abstract
Abstract Nanozymes, which are inorganic nanomaterials mimicking natural enzyme activities, are bringing enormous opportunities to theranostics. Herein, a cytochrome c oxidase‐like nanozyme (copper–silver alloy nanoparticle, Cu–Ag NP) is demonstrated for nanocatalytic cancer therapy. Loaded with bioreductive predrug (AQ4N), this Cu–Ag nanozyme unprecedentedly enables simultaneous starvation, ferroptosis, and chemical therapy with high specificity, and is able to totally eliminate tumor and greatly prolong the survival rate for 4T1‐tumor‐bearing mice. The underlying working mechanism is revealed both experimentally and theoretically.
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Research context
OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing 211816 China
School of Chemical and Biomedical Engineering Lee Kong Chian School of Medicine Nanyang Technological University 62 Nanyang Drive Singapore 637459 Singapore
School of Physical Science and Information Technology Liaocheng University Liaocheng 252059 China
Funding
National Natural Science Foundation of China
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