DataVXAdvanced MaterialsPaper
journal article·2018-06Open access

Multifunctional Nanohybrid Based on Porous Silicon Nanoparticles, Gold Nanoparticles, and Acetalated Dextran for Liver Regeneration and Acute Liver Failure Theranostics

Zehua Liu, Yunzhan Li, Wei Li, Chen Xiao, Dongfei Liu, Chao Dong, Ming Zhang, Ermei Mäkilä, Marianna Kemell, Jarno Salonen, Jouni T. Hirvonen, Hongbo Zhang, Dawang Zhou, Xianming Deng, Hélder A. Santos

Advanced Materials· Volume 30· Issue 24
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Source abstract

Abstract

Abstract Herein, a novel nanohybrid based on porous silicon, gold nanoparticles (Au NPs), and acetalated dextran (DPSi/DAu@AcDEX) is reported to encapsulate and deliver one drug and increase the computer tomography (CT) signal for acute‐liver‐failure (ALF) theranostics. A microfluidic‐assisted method is used to co‐encapsulate different NPs in a single step. By alternating the surface properties of different NPs and by modulating the composition of the organic phase, both PSi and Au NPs are effectively encapsulated into the polymer matrix simultaneously, thus further achieving a multifunctional application. This system can be used to identify pathologically changes in the tissues and selectively deliver drugs to these sites. The loading of a therapeutic compound (XMU‐MP‐1) improves the drug solubility, precise, in situ drug delivery, and the drug‐functioning time. In vivo results confirm a superior treatment effect and better compliance of this newly developed nanoformulation than free compound. This nanosystem plays a crucial role in targeting the lesion area, thus increasing the local drug concentration important for ALF reverse‐effect. Moreover, the residence of Au NPs within the matrix further endows our system for CT‐imaging. Altogether, these results support that this nanohybrid is a potential theranostic platform for ALF.
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Research context

PolymersNanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Pharmaceutical Chemistry and Technology Drug Research Program Faculty of Pharmacy University of Helsinki FI‐00014 Helsinki Finland

State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling, Network School of Life Sciences Xiamen University 361101 Fujian China

State‐Province Joint Engineering Laboratory of Targeted Drugs from Natural Products School of Life Sciences Xiamen University 361101 Fujian China

Helsinki Institute of Life Science (HiLIFE) University of Helsinki FI‐00014 Helsinki Finland

Laboratory of Industrial Physics Department of Physics University of Turku FI‐20014 Turku Finland

Department of Chemistry University of Helsinki FI‐00014 Helsinki Finland

Department of Pharmaceutical Science Åbo Akademi University FI‐20520 Turku Finland

Turku Center of Biotechnology Åbo Akademi University FI‐20520 Turku Finland

Funding

Orionin Tutkimussäätiö · Jane ja Aatos Erkon Säätiö · Terveyden Tutkimuksen Toimikunta · Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Helsingin Yliopisto · European Research Council

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