journal article·2017-03Open access

Light‐Enhancing Plasmonic‐Nanopore Biosensor for Superior Single‐Molecule Detection

Ossama N. Assad, Tal Gilboa, Joshua Spitzberg, Matyas Juhasz, Elmar Weinhold, Amit Meller

Advanced Materials· Volume 29· Issue 9

Abstract

A stacked plasmonic nanowell–nanopore biosensor strongly suppresses the background fluorescence from the bulk and yields net more than tenfold enhancement of the fluorescence intensity. The device offers extremely high signal-to-background (S/B) ratio for single-molecule detection at ultralow excitation laser intensities, while maintaining extremely high temporal bandwidth for single-DNA sensing. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Research context

OpenAlex topics: Nanopore and Nanochannel Transport Studies · Microfluidic and Bio-sensing Technologies · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical Engineering The Technion –Israel Institute of Technology Haifa 32000 Israel

Department of Biomedical Engineering Boston University Boston MA 02215 USA

Institute of Organic Chemistry RWTH Aachen University Landoltweg 1 Aachen 52056 Germany

Funding

Horizon 2020 · Israel Science Foundation

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