journal article·2009-11-26Open access

Translating Electronic Currents to Precise Acetylcholine–Induced Neuronal Signaling Using an Organic Electrophoretic Delivery Device

Klas Tybrandt, Karin C. Larsson, Sindhulakshmi Kurup, Daniel T. Simon, Peter Kjäll, Joakim Isaksson, Mats Sandberg, Edwin W. H. Jager, Agneta Richter‐Dahlfors, Magnus Berggren

Advanced Materials· Volume 21· Issue 44

Abstract

A miniaturized organic electronic ion pump (OEIP) based on conjugated polymers is developed for delivery of positively charged biomolecules. Characterization shows that applied voltage can precisely modulate the delivery rate of the neurotransmitter acetylcholine. The capability of the device is demonstrated by convection-free, spatiotemporally resolved delivery of acetylcholine via a 10 µm channel for dynamic stimulation of single neuronal cells.
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Research context

OpenAlex topics: Conducting polymers and applications · Neuroscience and Neural Engineering · Analytical Chemistry and Sensors

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