A Microfluidic Ion Pump for In Vivo Drug Delivery
Source abstract
Abstract
Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ‐amino butyric acid to a target solution, and demonstrates low‐voltage operation, high drug‐delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug‐delivery systems.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Neuroscience and Neural Engineering · Microfluidic and Capillary Electrophoresis Applications · Analytical Chemistry and Sensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Bioelectronics Ecole Nationale Supérieure des Mines CMP‐EMSE, MOC 13541 Gardanne France
Department of Electrical Engineering Columbia University NY 10027 USA
Biological and Environmental Science and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955‐6900 Kingdom of Saudi Arabia
Funding
Fondation pour la Recherche Médicale
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