journal article·2025-07-07

Remarkable Enhancement of the Radiotherapeutic Efficacy via Targeted Reduction of Hypoxic Conditions and Depletion of Intracellular Glutathione Utilizing Cu2–xSe@Pt Nanoplatforms

Beng Ma, Pingjuan Yang, Ying Yu, Jiayi Li, Haoyan Cheng, Anqi Ji, Fengqi Zhang, Wenxuan Fan, Hao Hu, Shegan Gao, Linlin Shi, Yan Yan, Kwun Nam Hui, Mingkai Liu

ACS Materials Letters· Volume 7· Issue 7
Publisher page

Abstract

Integrating multifunctional nanostructures to improve tumor microenvironment-mediated radiotherapy (RT) resistance combined with photothermal ablation represents a novel approach to killing tumor cells. In this work, we developed a synergistic nanoplatform (Cu 2– x Se@Pt, CS@Pt) capable of simultaneously addressing hypoxia, glutathione (GSH) overexpression, and energy deposition limitations. The mean lethal dose of radiation for KYSE30 tumor cells was significantly reduced by approximately 60% after CS@Pt incubation, decreasing from 4.92 to 1.97 Gy. Additionally, CS nanoparticles exhibit effective photothermal properties, enabling the CS@Pt formulation to integrate bioimaging with photothermal therapy (PTT) and RT, thereby creating a multifunctional nanoplatform for comprehensive tumor treatment. Both in vitro and in vivo experiments demonstrated that the combination of RT and PTT achieved complete tumor ablation, exhibiting excellent biosafety and potential for clinical translation.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Perovskite Materials and Applications · Luminescence Properties of Advanced Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Materials Science and Engineering, the First Affiliated Hospital of Henan University of Science and Technology

Henan University of Science and Technology

Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Henan Key Laboratory of Cancer Epigenetics, The First Affiliated Hospital, College of Clinical Medicine

Department of Radiation Oncology, Luoyang Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine

School of Chemistry & Chemical Engineering

Anhui University of Technology

Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China

Funding

Science Fund for Distinguished Young Scholars of Anhui Province · Natural Science Foundation of Henan Province · National Key Research and Development Program of China · Health Commission of Henan Province · Henan University of Science and Technology · Science and Technology Department of Henan Province · National Natural Science Foundation of China · National Clinical Key Specialty Construction Foundation of China · Central Plains Outstanding Young Leading Talents Program for Scientific and Technological Innovation · Key Research and Development Program of Xuzhou · Physician-Scientist Training Project in Henan Province

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