journal article·2010-12-07

Patterned Differentiation of Individual Embryoid Bodies in Spatially Organized 3D Hybrid Microgels

Hao Qi, Yanan Du, Lianyong Wang, Hirokazu Kaji, Hojae Bae, Ali Khademhosseini

Advanced Materials· Volume 22· Issue 46
Publisher page

Abstract

A microengineered hybrid hydrogel array is developed containing asymmetrical extracellular matrices [polyethylene-glycol (PEG) and gelatin methacrylate (GelMA)] to mimic the anisotropic stem cell niche and induce the patterned differentiation of embryoid bodies (EBs). The asymmetrical matrices around individual aggregate of mouse EBs induce polarity and demonstrate the potential of microscale engineered materials for forming tissues.
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Research context

OpenAlex topics: 3D Printing in Biomedical Research · Additive Manufacturing and 3D Printing Technologies · Pluripotent Stem Cells Research

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