DataVXAdvanced MaterialsPaper
journal article·2024-06

Microalgae‐Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression

Danni Zhong, Kangyu Jin, Ruoxi Wang, Bing Chen, Jinghui Zhang, Chaojie Ren, Xiaoyuan Chen, Jing Lu, Min Zhou

Advanced Materials· Volume 36· Issue 24
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Source abstract

Abstract

Abstract Patients diagnosed with inflammatory bowel disease (IBD) exhibit a notable prevalence of psychiatric disorders, such as anxiety and depression. Nevertheless, the etiology of psychiatric disorders associated with IBD remains uncertain, and an efficacious treatment approach has yet to be established. Herein, an oral hydrogel strategy (SP@Rh‐gel) is proposed for co‐delivery of Spirulina platensis and rhein to treat IBD and IBD‐associated anxiety and depression by modulating the microbiota‐gut‐brain axis. SP@Rh‐gel improves the solubility, release characteristics and intestinal retention capacity of the drug, leading to a significant improvement in the oral therapeutic efficacy. Oral administration of SP@Rh‐gel can reduce intestinal inflammation and rebalance the disrupted intestinal microbial community. Furthermore, SP@Rh‐gel maintains intestinal barrier integrity and reduces the release of pro‐inflammatory factors and their entry into the hippocampus through the blood‐brain barrier, thereby inhibiting neuroinflammation and maintaining neuroplasticity. SP@Rh‐gel significantly alleviates the colitis symptoms, as well as anxiety‐ and depression‐like behaviors, in a chronic colitis mouse model. This study demonstrates the significant involvement of the microbiota‐gut‐brain axis in the development of IBD with psychiatric disorders and proposes a safe, simple, and highly efficient therapeutic approach for managing IBD and comorbid psychiatric disorders.
Source: crossref · Quality: baseline

Research context

Polymers

OpenAlex topics: Gut microbiota and health · Tryptophan and brain disorders · Advanced Drug Delivery Systems

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Eye Center The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310000 P. R. China

Institute of Translational Medicine Zhejiang University Hangzhou 310029 P. R. China

Department of Psychiatry The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310000 P. R. China

School of Life Sciences Zhejiang Chinese Medical University Hangzhou 310053 P. R. China

Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore

Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore

Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Institute of Molecular and Cell Biology Agency for Science Technology and Research (A*STAR) 61 Biopolis Drive, Proteos Singapore 138673 Singapore

Zhejiang Key Laboratory of Precision Psychiatry Hangzhou 310003 P. R. China

Zhejiang University‐University of Edinburgh Institute (ZJU‐UoE Institute) Zhejiang University Haining 314400 P. R. China

National Key Laboratory of Biobased Transportation Fuel Technology Zhejiang University Hangzhou 310027 P. R. China

Zhejiang University‐Erdos Etuoke Joint Research Center The Second Affiliated Hospital Zhejiang University Hangzhou 310029 P. R. China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Medical Science and Technology Project of Zhejiang Province · China Postdoctoral Science Foundation · National University of Singapore

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