A Room Temperature Ionic Liquid (RTIL)‐Mediated, Non‐Hydrolytic Sol–Gel Methodology to Prepare Molecularly Imprinted, Silica‐Based Hybrid Monoliths for Chiral Separation

Silica-based hybrid molecularly imprinted polymer (MIP) monoliths with good chiral recognition ability are synthesized (see figure) using a novel method, a room temperature ionic liquid (RTIL)-mediated, non-hydrolytic sol–gel technique. The approach avoids the cracking and shrinking of the bed during drying, which is commonly associated with conventional sol–gel processing, overcomes the shortcomings associated with conventional organic-polymer-based MIP matrices, and offers improved selectivity.