journal article·2022-02

An NIR Discrete Metallacycle Constructed from Perylene Bisimide and Tetraphenylethylene Fluorophores for Imaging‐Guided Cancer Radio‐Chemotherapy

Yuan Ding, Zongrui Tong, Lulu Jin, Binglin Ye, Jiong Zhou, Zhongquan Sun, Huang Yang, Liangjie Hong, Feihe Huang, Weilin Wang, Zhengwei Mao

Advanced Materials· Volume 34· Issue 7
Publisher page

Abstract

Abstract To promote the clinical theranostic performances of platinum‐based anticancer drugs, imaging capability is urgently desired, and their chemotherapeutic efficacy needs to be upgraded. Herein, a theranostic metallacycle (M) is developed for imaging‐guided cancer radio‐chemotherapy using perylene bisimide fluorophore (PPy) and tetraphenylethylene‐based di‐Pt(II) organometallic precursor (TPE‐Pt) as building blocks. The formation of this discrete supramolecular coordination complex facilitates the encapsulation of M by a glutathione (GSH)‐responsive amphiphilic block copolymer to prepare M‐loaded nanoparticles (MNPs). TPE‐Pt acts as a chemotherapeutic drug and also an excellent radiosensitizer, thus incorporating radiotherapy into the nanomedicine to accelerate the therapeutic efficacy and overcome drug resistance. The NIR‐emission of PPy is employed to detect the intracellular delivery and tissue distribution of MNPs in real time. In vitro and in vivo investigations demonstrate the excellent anticancer efficacy combining chemotherapy and radiotherapy; the administration of this nanomedicine effectively inhibits the tumor growth and greatly extends the survival rate of cisplatin‐resistant A2780CIS‐tumor‐bearing mice. Guided by in vivo fluorescence imaging, radio‐chemotherapy is precisely carried out, which facilitates boosting of the therapeutic outcomes and minimizing undesired side effects. The success of this theranostic system brings new hope to supramolecular nanomedicines for their potential clinical translations.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310009 China

Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Zhejiang University Hangzhou Zhejiang 310009 China

Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province Zhejiang University Hangzhou Zhejiang 310009 China

Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University Zhejiang University Hangzhou Zhejiang 310009 China

Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province Zhejiang University Hangzhou Zhejiang 310009 China

MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China

Department of Chemistry College of Sciences Northeastern University Shenyang 110819 P. R. China

State Key Laboratory of Chemical Engineering Key Laboratory of Excited‐State Materials of Zhejiang Province Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University Hangzhou 310027 China

ZJU‐Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215 China

Green Catalysis Center and College of Chemistry Zhengzhou University Zhengzhou 450001 China

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities

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