DataVXAdvanced MaterialsPaper
journal article·2017-01

Thrombin‐Responsive Transcutaneous Patch for Auto‐Anticoagulant Regulation

Yuqi Zhang, Jicheng Yu, Jinqiang Wang, Nicholas J. Hanne, Zheng Cui, Chenggen Qian, Chao Wang, Hongliang Xin, Jacqueline H. Cole, Caterina M. Gallippi, Yong Zhu, Zhen Gu

Advanced Materials· Volume 29· Issue 4
Publisher page
Source abstract

Abstract

A thrombin-responsive closed-loop patch is developed for prolonged heparin delivery in a feedback-controlled manner. This microneedle-based patch can sense activated thrombin and subsequently releases heparin to prevent coagulation in the blood flow. This "smart" heparin patch can be transcutaneously inserted into skin without drug leakage and can sustainably regulate blood coagulation in response to thrombin.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advancements in Transdermal Drug Delivery · Blood properties and coagulation · Intramuscular injections and effects

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University Raleigh NC 27695 USA

Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics UNC Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Department of Mechanical and Aerospace Engineering North Carolina State University Raleigh NC 27695 USA

School of Pharmacy Nanjing Medical University Nanjing 211166 China

Department of Medicine University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Funding

NIH Clinical Center · National Science Foundation

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