DataVXAdvanced MaterialsPaper
journal article·2023-05

Young Exosome Bio‐Nanoparticles Restore Aging‐Impaired Tendon Stem/Progenitor Cell Function and Reparative Capacity

Shanshan Jin, Yu Wang, Xiaolan Wu, Zixin Li, Lisha Zhu, Yuting Niu, Yongsheng Zhou, Yan Liu

Advanced Materials· Volume 35· Issue 18
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Source abstract

Abstract

Abstract Aging impairs tendon stem/progenitor cell function and tendon homeostasis, however, effective treatments for aging‐induced tendon diseases are lacking. Exosomes are naturally derived nanoparticles that contain bioactive molecules, and therefore, have attracted great interest in tissue engineering and regenerative medicine. In this study, it is shown that young exosomes secreted by stem cells from human exfoliated deciduous teeth (SHED‐Exos) possess abundant anti‐aging signals. These young bio‐nanoparticles can alleviate the aging phenotypes of aged tendon stem/progenitor cells (AT‐SCs) and maintain their tenogenic capacity. Mechanistically, SHED‐Exos modulate histone methylation and inhibit nuclear factor‐κB to reverse AT‐SC aging. In a naturally aging mouse model, systemic administration of SHED‐Exo bio‐nanoparticles retards tendon degeneration. Interestingly, local delivery of SHED‐Exos‐loaded microspheres confers anti‐aging phenotypes, including reduced senescent cells and decreased ectopic bone formation, thereby functionally and structurally rescuing endogenous tendon regeneration and repair capacity in aged rats. Overall, SHED‐Exos, as natural bioactive nanoparticles, have promising translational and therapeutic potential for aging‐related diseases.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Tendon Structure and Treatment · Extracellular vesicles in disease · Periodontal Regeneration and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory of Biomimetic Nanomaterials Department of Orthodontics Peking University School and Hospital of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health NMPA Key Laboratory for Dental Materials Beijing 100081 P. R. China

Department of Prosthodontics Peking University School and Hospital of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health NMPA Key Laboratory for Dental Materials Beijing 100081 P. R. China

Funding

Beijing Nova Program · Natural Science Foundation of Beijing Municipality · China Postdoctoral Science Foundation

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