journal article·2005-10-04

Self‐Rupturing Microcapsules

B. G. De Geest, C. Déjugnat, G. B. Sukhorukov, K. Braeckmans, S. C. De Smedt, J. Demeester

Advanced Materials· Volume 17· Issue 19
Publisher page

Abstract

Self-rupturing microcapsules are prepared by layer-by-layer coating of degradable dextran-hydroxyethyl methacrylate microgels with the polyelectrolytes poly(allylamine hydrochloride) and sodium poly(styrene sulfonate). When the microgel core degrades, the swelling pressure increases and, at a critical value of the swelling pressure, the surrounding membrane suddenly ruptures (see Figure). This type of microcapsule could be very promising for pulsed drug delivery.
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Research context

OpenAlex topics: Polymer Surface Interaction Studies · Surface Modification and Superhydrophobicity · Electrospun Nanofibers in Biomedical Applications

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