Rational Design of Polyion Complex Nanoparticles to Overcome Cisplatin Resistance in Cancer Therapy

Rationally designed PIC nanoparticles as next-generation delivery system: we have developed a core–shell–corona PIC nanoparticle ⊕NP/[email protected] as a next-generation delivery system. ⊕NP/[email protected] exhibits prolonged circulation and enhanced drug accumulation in tumors. Subsequently, tumor pH leads to the release of ⊕NP/Pt, which facilitates cellular uptake followed by rapid intracellular cisplatin release. Using this delivery strategy cisplatin-resistant tumor growth in a murine xenograft model has been successfully suppressed. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.