Multimaterial 3D and 4D Bioprinting of Heterogenous Constructs for Tissue Engineering
Source abstract
Abstract
Abstract Additive manufacturing (AM), which is based on the principle of layer‐by‐layer shaping and stacking of discrete materials, has shown significant benefits in the fabrication of complicated implants for tissue engineering (TE). However, many native tissues exhibit anisotropic heterogenous constructs with diverse components and functions. Consequently, the replication of complicated biomimetic constructs using conventional AM processes based on a single material is challenging. Multimaterial 3D and 4D bioprinting (with time as the fourth dimension) has emerged as a promising solution for constructing multifunctional implants with heterogenous constructs that can mimic the host microenvironment better than single‐material alternatives. Notably, 4D‐printed multimaterial implants with biomimetic heterogenous architectures can provide a time‐dependent programmable dynamic microenvironment that can promote cell activity and tissue regeneration in response to external stimuli. This paper first presents the typical design strategies of biomimetic heterogenous constructs in TE applications. Subsequently, the latest processes in the multimaterial 3D and 4D bioprinting of heterogenous tissue constructs are discussed, along with their advantages and challenges. In particular, the potential of multimaterial 4D bioprinting of smart multifunctional tissue constructs is highlighted. Furthermore, this review provides insights into how multimaterial 3D and 4D bioprinting can facilitate the realization of next‐generation TE applications.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Additive Manufacturing and 3D Printing Technologies · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Centre for Advanced Structural Materials Department of Mechanical Engineering City University of Hong Kong Kowloon Hong Kong 999077 China
Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research Institute Greater Bay Joint Division Shenyang National Laboratory for Materials Science Shenzhen 518057 China
CityU‐Shenzhen Futian Research Institute Shenzhen 518045 China
State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China
Engineering Research Center of Ceramic Materials for Additive Manufacturing Ministry of Education Wuhan 430074 China
Department of Biomedical Sciences City University of Hong Kong Kowloon Hong Kong 999077 China
State Key Laboratory of High‐Performance Complex Manufacturing College of Mechanical and Electrical Engineering Central South University Changsha 410083 China
Department of Materials Science and Engineering City University of Hong Kong Kowloon Hong Kong 999077 China
Hong Kong Branch of National Precious Metals Material Engineering Research Center (NPMM) City University of Hong Kong Kowloon Hong Kong 999077 China
Funding
Guangdong Provincial Department of Science and Technology · Shenzhen Science and Technology Innovation Program · National Natural Science Foundation of China · Innovation and Technology Commission
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