DataVXAdvanced MaterialsPaper
journal article·2021-12

Anti‐Friction MSCs Delivery System Improves the Therapy for Severe Osteoarthritis

Xin Yan, Bo Yang, Yourong Chen, Yifan Song, Jing Ye, Yufan Pan, Bini Zhou, Yuqing Wang, Fengbiao Mao, Yuanchen Dong, Dongsheng Liu, Jiakuo Yu

Advanced Materials· Volume 33· Issue 52
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Source abstract

Abstract

Abstract Osteoarthritis (OA) is a musculoskeletal disorder disease affecting about 500 million people worldwide and mesenchymal sem cells (MSCs) therapy has been demonstrated as a potential strategy to treat OA. However, the shear forces during direct injection and the harsher shear condition of OA environments would lead to significant cell damage and inhibit the therapeutic efficacy. Herein, DNA supramolecular hydrogel has been applied as delivering material for MSCs to treat severe OA model, which perform extraordinary protection in MSCs against the shear force both in vitro and in vivo. It is demonstrated that the DNA supramolecular hydrogel can promote formation of quality cartilage, reduce osteophyte, and normalize subchondral bone under the high friction condition of OA, whose molecular mechanisms underlying therapeutic effects are also investigated. It can be anticipated that DNA supramolecular hydrogel would be a promising cell delivery system for multiple potential MSCs therapy.
Source: crossref · Quality: baseline

Research context

Polymers

OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Knee injuries and reconstruction techniques · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Sports Medicine Beijing Key Laboratory of Sports Injuries Peking University Third Hospital Beijing 100191 China

Institute of Sports Medicine Peking University Beijing 100191 China

Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology Department of Chemistry Tsinghua University Beijing 100084 China

Tsinghua Laboratory of Brain and Intelligence Tsinghua University Beijing 100084 China

Institute of Medical Innovation and Research Peking University Third Hospital Beijing 100191 China

Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China

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