journal article·2020-09

Tocilizumab–Conjugated Polymer Nanoparticles for NIR‐II Photoacoustic‐Imaging‐Guided Therapy of Rheumatoid Arthritis

Jingqin Chen, Ji Qi, Chao Chen, Jianhai Chen, Liangjian Liu, Rongkang Gao, Tiantian Zhang, Liang Song, Dan Ding, Peng Zhang, Chengbo Liu

Advanced Materials· Volume 32· Issue 37
Publisher page

Abstract

Abstract The progressive debilitating nature of rheumatoid arthritis (RA) combined with its unknown etiology and initial similarity to other inflammatory diseases makes early diagnosis a significant challenge. Early recognition and treatment of RA is essential for achieving effective therapeutic outcome. NIR‐II photoacoustic (PA) molecular imaging (PMI) is emerging as a promising new strategy for effective diagnosis and treatment guidance of RA, owing to its high sensitivity and specificity at large penetration depth. Herein, an antirheumatic targeted drug tocilizumab (TCZ) is conjugated to polymer nanoparticles (PNPs) to develop the first NIR‐II theranostic nanoplatform, named TCZ‐PNPs, for PA‐imaging‐guided therapy of RA. The TCZ‐PNPs are demonstrated to have strong NIR‐II extinction coefficient, high photostability and excellent biocompatibility. NIR‐II PMI results reveal the excellent targeting abilities of TCZ‐PNPs for the effective noninvasive diagnosis of RA joint tissue with a high signal‐to noise ratio (SNR) of 35.8 dB in 3D PA tomography images. Remarkably, one‐month treatment and PA monitoring using TCZ‐PNPs shows RA is significantly suppressed. In addition, the therapeutic evaluation of RA mice by NIR‐II PMI is shown to be consistent with clinical micro‐CT and histological analysis. The TCZ‐PNPs‐assisted NIR‐II PMI provides a new strategy for RA theranostics, therapeutic monitoring and the beyond.
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Research context

OpenAlex topics: Photoacoustic and Ultrasonic Imaging · Extracellular vesicles in disease · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Research Laboratory for Biomedical Optics and Molecular Imaging Shenzhen Key Laboratory for Molecular Imaging Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology CAS Key Laboratory of Health Informatics Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China

Shenzhen College of Advanced Technology University of Chinese Academy of Science Shenzhen 518055 China

Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School 300 Longwood Avenue Boston MA 02115 USA

State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education College of Life Sciences Nankai University 94 Weijin Road Tianjin 300071 China

Center for Translational Medicine Research and Development Shenzhen Engineering Research Center for Medical Bioactive Materials Shenzhen Institute of Advanced Technology Chinese Academy of Science Shenzhen 518055 China

Department of Rheumatology People's Hospital of Bao'an District Shenzhen 518128 China

Funding

National Natural Science Foundation of China · Chinese Academy of Sciences · Development and Reform Commission of Shenzhen Municipality

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