DataVXAdvanced MaterialsPaper
journal article·2022-04

Hybrid‐Membrane‐Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor‐Associated Macrophages Polarization and Hypoxia Relief

Lin Hou, Xuan Gong, Jing Yang, Huijuan Zhang, Weijing Yang, Xiaoyuan Chen

Advanced Materials· Volume 34· Issue 14
Publisher page
Source abstract

Abstract

Abstract Both tumor‐associated macrophages (TAMs) and hypoxia condition severely restrict the antitumor potency during cancer immunotherapy. It is essential to overcome the two issues for improving therapeutic efficacy. In this study, a hollow mesoporous Prussian blue (HMPB) nanosystem with mannose decoration and hydroxychloroquine (HCQ) adsorption is built, to form Man‐HMPB/HCQ. It can facilitate cellular internalization via mannose‐receptor mediated endocytosis and induce TAM polarization via iron ion/HCQ release with HMPB degradation. The hybrid macrophage and thylakoid (TK) membrane is camouflaged on the Man‐HMPB/HCQ surface, denoted as TK‐M@Man‐HMPB/HCQ, to reduce in vivo reticuloendothelial system uptake, enhance tumor accumulation, and mitigate hypoxia. The in vivo results indicate that TK‐M@Man‐HMPB/HCQ notably inhibits tumor growth, induces TAM polarization, facilitates cytotoxic T lymphocytes infiltration, and alleviates hypoxia microenvironment. The rational design may provide a new pathway to modulate the tumor microenvironment for promoting cancer immunotherapy effects.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Immune cells in cancer · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Pharmaceutical Sciences Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Henan Province Key Laboratory of Advanced Drug Preparation Technologies Ministry of Education Zhengzhou University Zhengzhou Henan 450001 China

Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering, and Biomedical Engineering Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119074 Singapore

Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore

Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Funding

National Natural Science Foundation of China

References (41)

Show source-provided references
1. 10.1002/adma.20180830310.1002/adma.201808303 ↗
2. 10.1002/adma.20200205410.1002/adma.202002054 ↗
3. 10.1016/j.immuni.2014.06.01010.1016/j.immuni.2014.06.010 ↗
4. 10.1016/S1471-4906(02)02302-510.1016/S1471-4906(02)02302-5 ↗
5. 10.1038/s41551-018-0236-810.1038/s41551-018-0236-8 ↗
6. 10.1002/adma.20190200710.1002/adma.201902007 ↗
7. 10.1038/s41565-018-0319-410.1038/s41565-018-0319-4 ↗
8. 10.1002/adma.20200485310.1002/adma.202004853 ↗
9. 10.1021/jacs.8b1090410.1021/jacs.8b10904 ↗
10. 10.1038/nnano.2016.16810.1038/nnano.2016.168 ↗
11. 10.1002/smll.20200354310.1002/smll.202003543 ↗
12. 10.1002/adhm.20190003910.1002/adhm.201900039 ↗
13. 10.1016/j.biomaterials.2019.11951510.1016/j.biomaterials.2019.119515 ↗
14. 10.1002/adma.20200054210.1002/adma.202000542 ↗
15. 10.1016/j.etap.2011.07.00210.1016/j.etap.2011.07.002 ↗
16. 10.1002/adhm.20180034710.1002/adhm.201800347 ↗
17. 10.1016/j.biomaterials.2014.04.00510.1016/j.biomaterials.2014.04.005 ↗
18. 10.1007/s00262-019-02415-810.1007/s00262-019-02415-8 ↗
19. 10.1002/adfm.20210283210.1002/adfm.202102832 ↗
20. 10.1016/j.jconrel.2020.06.02510.1016/j.jconrel.2020.06.025 ↗
21. 10.1038/s41568-021-00344-210.1038/s41568-021-00344-2 ↗
22. 10.1038/s41467-020-20723-x10.1038/s41467-020-20723-x ↗
23. 10.1021/acsnano.7b0904110.1021/acsnano.7b09041 ↗
24. 10.1016/j.addr.2017.04.01010.1016/j.addr.2017.04.010 ↗
25. 10.1002/adfm.20200355910.1002/adfm.202003559 ↗
26. 10.7150/thno.2011810.7150/thno.20118 ↗
27. 10.1021/acsnano.8b0406610.1021/acsnano.8b04066 ↗
28. 10.1016/j.cclet.2021.03.01510.1016/j.cclet.2021.03.015 ↗
29. 10.1038/nature1537310.1038/nature15373 ↗
30. 10.1093/nsr/nwz03710.1093/nsr/nwz037 ↗
31. 10.7150/thno.4784110.7150/thno.47841 ↗
32. 10.1021/acs.nanolett.7b0526310.1021/acs.nanolett.7b05263 ↗
33. 10.1016/j.cclet.2017.05.02310.1016/j.cclet.2017.05.023 ↗
34. 10.1016/j.actbio.2020.05.03510.1016/j.actbio.2020.05.035 ↗
35. 10.7150/thno.2246510.7150/thno.22465 ↗
36. 10.1158/0008-5472.CAN-15-347510.1158/0008-5472.CAN-15-3475 ↗
37. 10.1039/C8CC00674A10.1039/C8CC00674A ↗
38. 10.1126/sciadv.aaw687010.1126/sciadv.aaw6870 ↗
39. 10.1038/s41467-019-11157-110.1038/s41467-019-11157-1 ↗
40. 10.1002/adma.20160620910.1002/adma.201606209 ↗
41. 10.1016/j.biomaterials.2020.11993210.1016/j.biomaterials.2020.119932 ↗