Facile Synthesis of Efficient Luminogens with AIE Features for Three‐Photon Fluorescence Imaging of the Brain through the Intact Skull

Wei Qin; Nuernisha Alifu; Jacky W. Y. Lam; Yuhan Cui; Huifang Su; Guodong Liang; Jun Qian; Ben Zhong Tang

doi:10.1002/adma.202000364

journal article·2020-06

Facile Synthesis of Efficient Luminogens with AIE Features for Three‐Photon Fluorescence Imaging of the Brain through the Intact Skull

Wei Qin, Nuernisha Alifu, Jacky W. Y. Lam, Yuhan Cui, Huifang Su, Guodong Liang, Jun Qian, Ben Zhong Tang

Advanced Materials· Volume 32· Issue 23

Publisher page

Source abstract

Abstract

Abstract Visualization of the brain in its native environment is important for understanding common brain diseases. Herein, bright luminogens with remarkable aggregation‐induced emission (AIE) characteristics and high quantum yields of up to 42.6% in the solid state are synthesized through facile reaction routes. The synthesized molecule, namely BTF, shows ultrabright far‐red/near‐infrared emission and can be fabricated into AIE dots by a simple nanoprecipitation procedure. Due to their high brightness, large Stokes shift, good biocompatibility, satisfactory photostability, and large three‐photon absorption cross section, the AIE dots can be utilized as efficient fluorescent nanoprobes for in vivo brain vascular imaging through the intact skull by a three‐photon fluorescence microscopy imaging technique. This is the first example of using AIE dots for the visualization of the cerebral stroke process through the intact skull of a mouse with high penetration depth and good image contrast. Such good results are anticipated to open up a new venue in the development of efficient emitters with strong nonlinear optical effects for noninvasive bioimaging of living brain.

Source: crossref · Quality: baseline

Research context

Nanomaterials Biomaterials

OpenAlex topics: Luminescence and Fluorescent Materials · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

PCFM and GDHPPC Labs School of Materials Science and Engineering Sun Yat‐sen University Guangzhou 510275 China

State Key Laboratory of Modern Optical Instrumentations Center for Optical and Electromagnetic Research JORCEP (Sino‐Swedish Joint Research Center of photonics) Zhejiang University Hangzhou 310058 China

College of Medical Engineering and Technology Xinjiang Medical University Urumqi 830011 China

Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong

Department of Orthopaedic Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province 450052 China

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Natural Science Foundation of Zhejiang Province · Innovation and Technology Commission

References (55)

Show source-provided references

1. 10.1021/jacs.5b0409710.1021/jacs.5b04097 ↗

2. 10.1002/smll.20160087210.1002/smll.201600872 ↗

3. 10.1002/adfm.20190271710.1002/adfm.201902717 ↗

4. 10.1002/adma.20130193810.1002/adma.201301938 ↗

5. 10.1038/nmeth81810.1038/nmeth818 ↗

6. 10.1021/jacs.8b1141410.1021/jacs.8b11414 ↗

7. 10.1038/nn.435810.1038/nn.4358 ↗

8. 10.1038/nprot.2009.22210.1038/nprot.2009.222 ↗

9. 10.1038/nn188310.1038/nn1883 ↗

10. 10.1021/acs.analchem.9b0262410.1021/acs.analchem.9b02624 ↗

11. 10.1073/pnas.150593911210.1073/pnas.1505939112 ↗

12. Wang D. · 2019

13. 10.1038/s41592-018-0115-y10.1038/s41592-018-0115-y ↗

14. 10.1038/s41467-018-08179-610.1038/s41467-018-08179-6 ↗

15. 10.1038/nmeth.418310.1038/nmeth.4183 ↗

16. 10.1038/nmat360810.1038/nmat3608 ↗

17. 10.1002/adfm.20180836510.1002/adfm.201808365 ↗

18. 10.1038/s41377-018-0012-210.1038/s41377-018-0012-2 ↗

19. 10.1021/acs.bioconjchem.6b0065410.1021/acs.bioconjchem.6b00654 ↗

20. 10.1038/nmat356510.1038/nmat3565 ↗

21. 10.1021/cr050054x10.1021/cr050054x ↗

22. 10.1021/nl034733410.1021/nl0347334 ↗

23. 10.1021/acs.chemrev.9b0040410.1021/acs.chemrev.9b00404 ↗

24. 10.1039/C7CS00907K10.1039/C7CS00907K ↗

25. 10.1021/acs.chemrev.8b0026010.1021/acs.chemrev.8b00260 ↗

26. 10.1002/adma.20190353010.1002/adma.201903530 ↗

27. 10.1039/C7QM00201G10.1039/C7QM00201G ↗

28. 10.1002/adbi.20180007410.1002/adbi.201800074 ↗

29. 10.1002/adma.20180210510.1002/adma.201802105 ↗

30. 10.1002/adfm.20170468910.1002/adfm.201704689 ↗

31. 10.1002/adma.20190491410.1002/adma.201904914 ↗

32. 10.1002/adma.20180633110.1002/adma.201806331 ↗

33. 10.1021/acsami.7b1434310.1021/acsami.7b14343 ↗

34. 10.1039/C7SC04820C10.1039/C7SC04820C ↗

35. 10.1021/acs.nanolett.8b0393610.1021/acs.nanolett.8b03936 ↗

36. 10.1021/acsnano.7b0564510.1021/acsnano.7b05645 ↗

37. 10.1073/pnas.190850311610.1073/pnas.1908503116 ↗

38. 10.1073/pnas.181734711610.1073/pnas.1817347116 ↗

39. 10.1038/nm.272110.1038/nm.2721 ↗

40. 10.1039/C6RA23507G10.1039/C6RA23507G ↗

41. 10.1002/adma.20180076610.1002/adma.201800766 ↗

42. 10.1002/adma.20140135610.1002/adma.201401356 ↗

43. 10.1021/acs.chemmater.5b0056810.1021/acs.chemmater.5b00568 ↗

44. 10.1021/cr940745l10.1021/cr940745l ↗

45. 10.1039/C5TC03933A10.1039/C5TC03933A ↗

46. 10.1021/jp902962h10.1021/jp902962h ↗

47. 10.1002/anie.20090451510.1002/anie.200904515 ↗

48. 10.1364/OE.3.00031510.1364/OE.3.000315 ↗

49. 10.1063/1.11844210.1063/1.118442 ↗

50. 10.1021/jp205238q10.1021/jp205238q ↗

51. 10.1021/nn507072r10.1021/nn507072r ↗

52. 10.1038/nphoton.2012.33610.1038/nphoton.2012.336 ↗

53. 10.1002/adma.20190444710.1002/adma.201904447 ↗

54. 10.1039/C7TB00156H10.1039/C7TB00156H ↗

55. 10.1002/adma.20150014110.1002/adma.201500141 ↗