journal article·2023-06

Coupling Probiotics with 2D CoCuMo‐LDH Nanosheets as a Tumor‐Microenvironment‐Responsive Platform for Precise NIR‐II Photodynamic Therapy

Yu Yang, Tingting Hu, Yixin Bian, Fanqi Meng, Shilong Yu, Hai Li, Qinghua Zhang, Lin Gu, Xisheng Weng, Chaoliang Tan, Ruizheng Liang

Advanced Materials· Volume 35· Issue 23
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Abstract

Abstract Photodynamic therapy (PDT) has become a promising cancer treatment approach with superior advantages. However, it remains a grand challenge to develop tumor microenvironment (TME)‐responsive photosensitizers (PSs) for tumor‐targeting precise PDT. Herein, the coupling Lactobacillus acidophilus (LA) probiotics with 2D CoCuMo layered‐double‐hydroxide (LDH) nanosheets (LA&LDH) is reported as a TME‐responsive platform for precise NIR‐II PDT. The CoCuMo‐LDH nanosheets loaded on LA can be transformed from crystalline into amorphous through etching by the LA‐metabolite‐enabled low pH and overexpressed glutathione. The TME‐induced in situ amorphization of CoCuMo‐LDH nanosheets can boost its photodynamic activity for singlet oxygen (1O2) generation under 1270 nm laser irradiation with relative 1O2 quantum yield of 1.06, which is the highest among previously reported NIR‐excited PSs. In vitro and in vivo assays prove that the LA&LDH can effectively achieve complete cell apoptosis and tumor eradication under 1270 nm laser irradiation. This study proves that the probiotics can be used as a tumor‐targeting platform for highly efficient precise NIR‐II PDT.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Photocatalysis Techniques · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China

Department of Orthopedic Surgery State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 P. R. China

Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 P. R. China

Institute of Advanced Materials (IAM) and Key Laboratory of Flexible Electronics (KLoFE) Nanjing Tech University (NanjingTech) 30 South Puzhu Road Nanjing 211816 P. R. China

School of Materials Science and Engineering Tsinghua University Beijing 100084 P. R. China

Department of Chemistry and Center of Super‐Diamond and Advanced Films (COSDAF) City University of Hong Kong Kowloon Hong Kong SAR 999077 P. R. China

Shenzhen Research Institute City University of Hong Kong Shenzhen 518057 P. R. China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Beijing Municipality

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